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. 2020 Oct;56(10):1565-1569.
doi: 10.1111/jpc.15019. Epub 2020 Jul 16.

Neonatal Candida auris infection: Management and prevention strategies - A single centre experience

Jayasree Chandramati  1 , Laleet Sadanandan  1 , Anil Kumar  2 , Sasidharan Ponthenkandath  1
Affiliations

Neonatal Candida auris infection: Management and prevention strategies - A single centre experience

Jayasree Chandramati et al. J Paediatr Child Health. 2020 Oct.

Abstract

Aim: Our aim was to identify the clinical features and outcome of multidrug resistant Candida auris (CA) infection in neonates.

Methods: This is a retrospective case cohort study of 17 neonates who developed sepsis caused by CA infection in a tertiary care neonatal intensive care unit over 3 years. The risk factors, clinical features, treatment and outcome were studied.

Results: The mean gestation was 32.4 ± 4.9 weeks with overall mortality of 41%. Clinical features were indistinguishable from other causes of sepsis. CA was sensitive to micafungin but resistant to fluconazole and had variable sensitivity to voriconazole and amphotericin. Survival improved to 83% when infants were treated with a combination of micafungin and amphotericin. Non-survivors were of lower birthweights and had other risk factors.

Conclusions: The management guidelines and infection control measures are described in this largest series of neonatal CA infection. Treatment with a combination of amphotericin and micafungin improved the outcome.

Keywords: Candida auris; late onset sepsis; neonates; outcome.

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References

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