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. 2021 May 18;72(10):1834-1837.
doi: 10.1093/cid/ciaa1007.

Excess Soluble fms-like Tyrosine Kinase 1 Correlates With Endothelial Dysfunction and Organ Failure in Critically Ill Coronavirus Disease 2019 Patients

Vincent Dupont  1   2 , Lukshe Kanagaratnam  3 , Antoine Goury  1 , Gaël Poitevin  2 , Mathieu Bard  1 , Gauthier Julien  1 , Michel Bonnivard  1 , Vanessa Champenois  1 , Violaine Noel  4 , Bruno Mourvillier  1 , Philippe Nguyen  2
Affiliations

Excess Soluble fms-like Tyrosine Kinase 1 Correlates With Endothelial Dysfunction and Organ Failure in Critically Ill Coronavirus Disease 2019 Patients

Vincent Dupont et al. Clin Infect Dis. .

Abstract

Excess soluble fms-like tyrosine kinase 1 (sFlt-1), a soluble inhibitor of vascular endothelial growth factor pathway, has been demonstrated to promote endothelial dysfunction. Here, we demonstrate that sFlt-1 plasma levels correlate with respiratory symptom severity, expression of endothelial dysfunction biomarker, and incidence of organ failure in coronavirus disease 2019 patients. Clinical Trials Registration: NCT04394195.

Keywords: COVID-19; critical care; endothelial dysfunction; sFlt-1.

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