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Review
. 2020 Sep 1;129(3):516-521.
doi: 10.1152/japplphysiol.00319.2020. Epub 2020 Jul 16.

Making Mice Mighty: recent advances in translational models of load-induced muscle hypertrophy

Kevin A Murach  1   2 , John J McCarthy  1   3 , Charlotte A Peterson  1   2   3 , Cory M Dungan  1   2
Affiliations
Review

Making Mice Mighty: recent advances in translational models of load-induced muscle hypertrophy

Kevin A Murach et al. J Appl Physiol (1985). .

Abstract

The ability to genetically manipulate mice allows for gain- and loss-of-function in vivo, making them an ideal model for elucidating mechanisms of skeletal muscle mass regulation. Combining genetic models with mechanical muscle loading enables identification of specific factors involved in the hypertrophic response as well as the ability to test the requirement of those factors for adaptation, thereby informing performance and therapeutic interventions. Until recently, approaches for inducing mechanically mediated muscle hypertrophy (i.e., resistance-training analogs) have been limited and considered "nontranslatable" to humans. This mini-review outlines recent translational advances in loading-mediated strategies for inducing muscle hypertrophy in mice, and highlights the advantages and disadvantages of each method. The skeletal muscle field is poised for new breakthroughs in understanding mechanisms regulating load-induced muscle growth given the numerous murine tools that have very recently been described.

Keywords: PoWeR; electrical stimulation; fiber type; resistance training; running.

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Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the authors.

References

    1. Adams GR, Bamman MM. Characterization and regulation of mechanical loading-induced compensatory muscle hypertrophy. Compr Physiol 2: 2829–2870, 2012. doi: 10.1002/cphy.c110066. - DOI - PubMed
    1. al-Majid S, McCarthy DO. Resistance exercise training attenuates wasting of the extensor digitorum longus muscle in mice bearing the colon-26 adenocarcinoma. Biol Res Nurs 2: 155–166, 2001. doi: 10.1177/109980040100200301. - DOI - PubMed
    1. Allen DL, Harrison BC, Maass A, Bell ML, Byrnes WC, Leinwand LA. Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse. J Appl Physiol (1985) 90: 1900–1908, 2001. doi: 10.1152/jappl.2001.90.5.1900. - DOI - PubMed
    1. Baar K, Esser K. Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise. Am J Physiol Cell Physiol 276: C120–C127, 1999. doi: 10.1152/ajpcell.1999.276.1.C120. - DOI - PubMed
    1. Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, Zlotchenko E, Scrimgeour A, Lawrence JC, Glass DJ, Yancopoulos GD. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol 3: 1014–1019, 2001. doi: 10.1038/ncb1101-1014. - DOI - PubMed

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