The interaction between SARS-CoV-2 and ACE2 may have consequences for skeletal muscle viral susceptibility and myopathies

doi:10.1152/japplphysiol.00321.2020

Review

. 2020 Oct 1;129(4):864-867.

doi: 10.1152/japplphysiol.00321.2020. Epub 2020 Jul 16.

The interaction between SARS-CoV-2 and ACE2 may have consequences for skeletal muscle viral susceptibility and myopathies

Peter J Ferrandi^{1

2}, Stephen E Alway^{3

2}, Junaith S Mohamed^{1

2}

Affiliations

¹ Laboratory of Muscle and Nerve, Department of Diagnostic and Health Sciences, College of Health Professions, University of Tennessee Health Science Center, Memphis, Tennessee.
² Center for Muscle, Metabolism and Neuropathology, Division of Rehabilitation Sciences, College of Health Professions, University of Tennessee Health Science Center, Memphis, Tennessee.
³ Laboratory of Muscle Biology and Sarcopenia, Department of Physical Therapy, College of Health Professions, University of Tennessee Health Science Center, Memphis, Tennessee.

PMID: 32673162
PMCID: PMC7832004
DOI: 10.1152/japplphysiol.00321.2020

Review

The interaction between SARS-CoV-2 and ACE2 may have consequences for skeletal muscle viral susceptibility and myopathies

Peter J Ferrandi et al. J Appl Physiol (1985). 2020.

. 2020 Oct 1;129(4):864-867.

doi: 10.1152/japplphysiol.00321.2020. Epub 2020 Jul 16.

Authors

Peter J Ferrandi^{1

2}, Stephen E Alway^{3

2}, Junaith S Mohamed^{1

2}

Affiliations

¹ Laboratory of Muscle and Nerve, Department of Diagnostic and Health Sciences, College of Health Professions, University of Tennessee Health Science Center, Memphis, Tennessee.
² Center for Muscle, Metabolism and Neuropathology, Division of Rehabilitation Sciences, College of Health Professions, University of Tennessee Health Science Center, Memphis, Tennessee.
³ Laboratory of Muscle Biology and Sarcopenia, Department of Physical Therapy, College of Health Professions, University of Tennessee Health Science Center, Memphis, Tennessee.

PMID: 32673162
PMCID: PMC7832004
DOI: 10.1152/japplphysiol.00321.2020

No abstract available

Keywords: COVID-19; SARS-CoV-2; muscular dystrophy; myopathy; respiration; sarcopenia; skeletal muscle.

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Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the authors.

Figures

**Fig. 1.**
Representative diagram displays the potential spread of SARS-CoV-2 into skeletal muscle and the cause of myopathies.

See this image and copyright information in PMC

Comment in

Commentaries on Viewpoint: The interaction between SARS-CoV-2 and ACE2 may have consequences for skeletal muscle viral susceptibility and myopathies.
Tan AL, Farrow M, Biglands J, Fernandes RJ, Abraldes JA, de Souza Castro FA, de Souza HL, Arriel RA, Meireles A, Marocolo M, González-Rayas JM, Rayas-Gómez AL, Mobayed-Vega FN, González-Yáñez JM, Hirai DM, Belbis MD, Holmes MJ, Calvo N, Ferguson SK, Fernandes T, Oliveira EM, Pun M, Bhandari SS. Tan AL, et al. J Appl Physiol (1985). 2020 Oct 1;129(4):868-871. doi: 10.1152/japplphysiol.00775.2020. J Appl Physiol (1985). 2020. PMID: 33027604 Free PMC article. No abstract available.
Last Word on Viewpoint: The interaction between SARS-CoV-2 and ACE2 may have consequences for skeletal muscle viral susceptibility and myopathies.
Ferrandi PJ, Alway SE, Mohamed JS. Ferrandi PJ, et al. J Appl Physiol (1985). 2020 Oct 1;129(4):872. doi: 10.1152/japplphysiol.00785.2020. J Appl Physiol (1985). 2020. PMID: 33027605 Free PMC article. No abstract available.

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References

1. Alway SE, Myers MJ, Mohamed JS. Regulation of satellite cell function in sarcopenia. Front Aging Neurosci 6: 246, 2014. doi:10.3389/fnagi.2014.00246. - DOI - PMC - PubMed
1. Byun MK, Cho EN, Chang J, Ahn CM, Kim HJ. Sarcopenia correlates with systemic inflammation in COPD. Int J Chron Obstruct Pulmon Dis 12: 669–675, 2017. doi:10.2147/COPD.S130790. - DOI - PMC - PubMed
1. D’Souza DM, Al-Sajee D, Hawke TJ. Diabetic myopathy: impact of diabetes mellitus on skeletal muscle progenitor cells. Front Physiol 4: 379, 2013. doi:10.3389/fphys.2013.00379. - DOI - PMC - PubMed
1. Deyhle MR, Hyldahl RD. The role of T lymphocytes in skeletal muscle repair from traumatic and contraction-induced injury. Front Physiol 9: 768, 2018. doi:10.3389/fphys.2018.00768. - DOI - PMC - PubMed
1. Giordani L, He GJ, Negroni E, Sakai H, Law JYC, Siu MM, Wan R, Corneau A, Tajbakhsh S, Cheung TH, Le Grand F. High-dimensional single-cell cartography reveals novel skeletal muscle-resident cell populations. Mol Cell 74: 609–621.e6, 2019. doi:10.1016/j.molcel.2019.02.026. - DOI - PubMed

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[1] Alway SE, Myers MJ, Mohamed JS. Regulation of satellite cell function in sarcopenia. Front Aging Neurosci 6: 246, 2014. doi:10.3389/fnagi.2014.00246. - DOI - PMC - PubMed

[2] Alway SE, Myers MJ, Mohamed JS. Regulation of satellite cell function in sarcopenia. Front Aging Neurosci 6: 246, 2014. doi:10.3389/fnagi.2014.00246. - DOI - PMC - PubMed

[3] Byun MK, Cho EN, Chang J, Ahn CM, Kim HJ. Sarcopenia correlates with systemic inflammation in COPD. Int J Chron Obstruct Pulmon Dis 12: 669–675, 2017. doi:10.2147/COPD.S130790. - DOI - PMC - PubMed

[4] Byun MK, Cho EN, Chang J, Ahn CM, Kim HJ. Sarcopenia correlates with systemic inflammation in COPD. Int J Chron Obstruct Pulmon Dis 12: 669–675, 2017. doi:10.2147/COPD.S130790. - DOI - PMC - PubMed

[5] D’Souza DM, Al-Sajee D, Hawke TJ. Diabetic myopathy: impact of diabetes mellitus on skeletal muscle progenitor cells. Front Physiol 4: 379, 2013. doi:10.3389/fphys.2013.00379. - DOI - PMC - PubMed

[6] D’Souza DM, Al-Sajee D, Hawke TJ. Diabetic myopathy: impact of diabetes mellitus on skeletal muscle progenitor cells. Front Physiol 4: 379, 2013. doi:10.3389/fphys.2013.00379. - DOI - PMC - PubMed

[7] Deyhle MR, Hyldahl RD. The role of T lymphocytes in skeletal muscle repair from traumatic and contraction-induced injury. Front Physiol 9: 768, 2018. doi:10.3389/fphys.2018.00768. - DOI - PMC - PubMed

[8] Deyhle MR, Hyldahl RD. The role of T lymphocytes in skeletal muscle repair from traumatic and contraction-induced injury. Front Physiol 9: 768, 2018. doi:10.3389/fphys.2018.00768. - DOI - PMC - PubMed

[9] Giordani L, He GJ, Negroni E, Sakai H, Law JYC, Siu MM, Wan R, Corneau A, Tajbakhsh S, Cheung TH, Le Grand F. High-dimensional single-cell cartography reveals novel skeletal muscle-resident cell populations. Mol Cell 74: 609–621.e6, 2019. doi:10.1016/j.molcel.2019.02.026. - DOI - PubMed

[10] Giordani L, He GJ, Negroni E, Sakai H, Law JYC, Siu MM, Wan R, Corneau A, Tajbakhsh S, Cheung TH, Le Grand F. High-dimensional single-cell cartography reveals novel skeletal muscle-resident cell populations. Mol Cell 74: 609–621.e6, 2019. doi:10.1016/j.molcel.2019.02.026. - DOI - PubMed

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The interaction between SARS-CoV-2 and ACE2 may have consequences for skeletal muscle viral susceptibility and myopathies

Affiliations

The interaction between SARS-CoV-2 and ACE2 may have consequences for skeletal muscle viral susceptibility and myopathies

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