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. 2020 Dec;9(1):1744-1747.
doi: 10.1080/22221751.2020.1796529.

Rapid inactivation of SARS-CoV-2 with deep-UV LED irradiation

Hiroko Inagaki  1 , Akatsuki Saito  2   3 , Hironobu Sugiyama  1   4 , Tamaki Okabayashi  2   3 , Shouichi Fujimoto  5
Affiliations

Rapid inactivation of SARS-CoV-2 with deep-UV LED irradiation

Hiroko Inagaki et al. Emerg Microbes Infect. 2020 Dec.

Abstract

The spread of novel coronavirus disease 2019 (COVID-19) infections worldwide has raised concerns about the prevention and control of SARS-CoV-2. Devices that rapidly inactivate viruses can reduce the chance of infection through aerosols and contact transmission. This in vitro study demonstrated that irradiation with a deep ultraviolet light-emitting diode (DUV-LED) of 280 ± 5 nm wavelength rapidly inactivates SARS-CoV-2 obtained from a COVID-19 patient. Development of devices equipped with DUV-LED is expected to prevent virus invasion through the air and after touching contaminated objects.

Keywords: COVID-19; SARS-CoV-2; antiviral efficacy; contact transmission; deep-UV LED; fomite infection; inactivation.

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Conflict of interest statement

H.S. receives part of his salary from Nikkiso Co., Ltd., Tokyo, Japan. Nikkiso supplied the deep ultraviolet light-emitting diode (DUV-LED) instrument for evaluation. Nikkiso had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The other authors declare no conflicts of interest.

Figures

Figure 1.
Figure 1.
Inhibitory effects of DUV-irradiation on SARS-CoV-2. (A) Cytopathic changes in virus-infected Vero cells without DUV-LED irradiation (0 s), or with DUV-LED irradiation for 1, 10, 20, 30 or 60 s, and each dose corresponding to 3.75, 37.5, 75, 112.5 or 225 mJ/cm2, respectively. (B) Plaque formation in Vero cells. Virus solutions irradiated with DUV-LED for several durations were diluted (100-fold) and inoculated to Vero cells. A representative result is shown. (C) Time-dependent inactivation of SARS-CoV-2 by DUV-LED irradiation. The results shown are the mean and standard deviation (SD) of triplicate measurements.
See this image and copyright information in PMC

References

    1. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/2....
    1. Wang W, Xu Y, Gao R, et al. . Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. 2020;323(18):1843–1844. - PMC - PubMed
    1. Sun J, Zhu A, Li H, et al. . Isolation of infectious SARS-CoV-2 from urine of a COVID-19 patient. Emerg Microbes Infect. 2020;9(1):991–993. doi: 10.1080/22221751.2020.1760144 - DOI - PMC - PubMed
    1. van Doremalen N, Bushmaker T, Morris DH, et al. . Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med. 2020;382(16):1564–1567. doi: 10.1056/NEJMc2004973 - DOI - PMC - PubMed
    1. Matson MJ, Kwe Yinda C, Seifert SN, et al. . Effect of environmental conditions on SARS-CoV-2 stability in human nasal mucus and sputum. Emerg Infect Dis. Published online 2020 June 8. - PMC - PubMed

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