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Editorial
. 2020 Jul 17;127(3):391-393.
doi: 10.1161/CIRCRESAHA.120.317423. Epub 2020 Jul 16.

Protective Function of MCUb in Postischemic Remodeling Getting at the Heart of the Calcium Control Conundrum

Alexandra G Moyzis  1 , Åsa B Gustafsson  1
Affiliations
Editorial

Protective Function of MCUb in Postischemic Remodeling Getting at the Heart of the Calcium Control Conundrum

Alexandra G Moyzis et al. Circ Res. .
No abstract available

Keywords: Editorials; calcium; cell survival; homeostasis; mitochondria; myocardial ischemia.

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Figures

Figure 1.
Figure 1.. MCUb prevents mitochondrial calcium influx and protects the myocyte mitochondria against calcium overload and mPTP opening during post-infarct remodeling.
A. Ischemic injury causes calcium influx and overload through the MCU channel that leads to mPTP opening and cell death. B. MCUb protects mitochondria against calcium overload in response to ischemic injury by inhibiting MCU-mediated calcium uptake. This leads to decreased mPTP opening and reduced cell death. Ca2+ indicates calcium, mPTP indicates mitochondrial permeability transition pore, IMS indicates intermembrane space, and IMM indicates inner mitochondrial membrane.
See this image and copyright information in PMC

Comment on

References

    1. Balaban RS. The role of Ca(2+) signaling in the coordination of mitochondrial ATP production with cardiac work. Biochim Biophys Acta. 2009;1787:1334–41. - PMC - PubMed
    1. Rasola A and Bernardi P. Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis. Cell Calcium. 2011;50:222–33. - PubMed
    1. Perocchi F, Gohil VM, Girgis HS, Bao XR, McCombs JE, Palmer AE and Mootha VK. MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Nature. 2010;467:291–6. - PMC - PubMed
    1. De Stefani D, Raffaello A, Teardo E, Szabo I and Rizzuto R. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature. 2011;476:336–40. - PMC - PubMed
    1. Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, et al. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature. 2011;476:341–5. - PMC - PubMed