Immune responses to rhinoviruses and asthma: Are we 3 steps closer to the door?

Affiliations

Editorial

James E Gern. J Allergy Clin Immunol. 2020 Sep.

. 2020 Sep;146(3):513-514.

doi: 10.1016/j.jaci.2020.06.031. Epub 2020 Jul 14.

¹ Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, Wis. Electronic address: gern@medicine.wisc.edu.

No abstract available

Keywords: Rhinovirus; T cells; age; allergy; asthma; inoculation; mouse; omalizumab.

Comment on

Understanding the asthmatic response to an experimental rhinovirus infection: Exploring the effects of blocking IgE.
Heymann PW, Platts-Mills TAE, Woodfolk JA, Borish L, Murphy DD, Carper HT, Conaway MR, Steinke JW, Muehling L, Gerald Teague W, Kennedy JL, Irani AM, McGraw MD, Early SV, Wheatley LM, Adams AP, Turner RB. Heymann PW, et al. J Allergy Clin Immunol. 2020 Sep;146(3):545-554. doi: 10.1016/j.jaci.2020.01.035. Epub 2020 Feb 1. J Allergy Clin Immunol. 2020. PMID: 32018030 Free PMC article. Clinical Trial.
Human T_H1 and T_H2 cells targeting rhinovirus and allergen coordinately promote allergic asthma.
Muehling LM, Heymann PW, Wright PW, Eccles JD, Agrawal R, Carper HT, Murphy DD, Workman LJ, Word CR, Ratcliffe SJ, Capaldo BJ, Platts-Mills TAE, Turner RB, Kwok WW, Woodfolk JA. Muehling LM, et al. J Allergy Clin Immunol. 2020 Sep;146(3):555-570. doi: 10.1016/j.jaci.2020.03.037. Epub 2020 Apr 19. J Allergy Clin Immunol. 2020. PMID: 32320734 Free PMC article.
Early-life heterologous rhinovirus infections induce an exaggerated asthma-like phenotype.
Rajput C, Han M, Ishikawa T, Lei J, Jazaeri S, Bentley JK, Hershenson MB. Rajput C, et al. J Allergy Clin Immunol. 2020 Sep;146(3):571-582.e3. doi: 10.1016/j.jaci.2020.03.039. Epub 2020 Apr 25. J Allergy Clin Immunol. 2020. PMID: 32344055 Free PMC article.