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Editorial
. 2020 Jul 21;76(3):277-279.
doi: 10.1016/j.jacc.2020.06.003.

Renin-Angiotensin System Blockade in COVID-19: Good, Bad, or Indifferent?

Michael J Bloch  1
Affiliations
Editorial

Renin-Angiotensin System Blockade in COVID-19: Good, Bad, or Indifferent?

Michael J Bloch. J Am Coll Cardiol. .
No abstract available

Keywords: COVID-19; SARS-CoV-2; renin-angiotensin; transcatheter aortic valve replacement.

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Figures

None
Graphical abstract
Figure 1
Figure 1
Interaction of COVID Infection and RAS Binding of COVID spike protein to ACE2 on cell surface leads to infection and a decrease in ACE2 available to degrade angiotensin II to angiotensin 1-7, tilting the balance toward adverse effects of angiotensin II type I receptor activation. ACE = angiotensin-converting enzyme; ARB = angiotensin receptor blocker; RAS = renin-angiotensin syndrome; SARS-CoV-2 = severe acute respiratory syndrome-coronavirus-2;TMPRSS2 = transmembrane protease, serine 2.
See this image and copyright information in PMC

Comment on

  • Ramipril in High-Risk Patients With COVID-19.
    Amat-Santos IJ, Santos-Martinez S, López-Otero D, Nombela-Franco L, Gutiérrez-Ibanes E, Del Valle R, Muñoz-García E, Jiménez-Diaz VA, Regueiro A, González-Ferreiro R, Benito T, Sanmartin-Pena XC, Catalá P, Rodríguez-Gabella T, Delgado-Arana JR, Carrasco-Moraleja M, Ibañez B, San Román JA. Amat-Santos IJ, et al. J Am Coll Cardiol. 2020 Jul 21;76(3):268-276. doi: 10.1016/j.jacc.2020.05.040. Epub 2020 May 26. J Am Coll Cardiol. 2020. PMID: 32470515 Free PMC article.

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