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. 2020 Mar-Apr;61(2):60-66.
doi: 10.4103/nmj.NMJ_31_19. Epub 2020 May 7.

Prevalence and Factors Associated with Neonatal Sepsis in a Tertiary Hospital, North West Nigeria

Abdulhakeem Abayomi Olorukooba  1 , Williams Richard Ifusemu  2 , Muhammed Sani Ibrahim  1 , Muhammad Bashar Jibril  1 , Lawal Amadu  3 , Bola Biliaminu Lawal  4
Affiliations

Prevalence and Factors Associated with Neonatal Sepsis in a Tertiary Hospital, North West Nigeria

Abdulhakeem Abayomi Olorukooba et al. Niger Med J. 2020 Mar-Apr.

Abstract

Context: Neonatal sepsis is an important cause of morbidity and mortality of newborns, especially in developing countries.

Aims: Our study determined the prevalence of neonatal sepsis and its predisposing factors among neonates admitted in Ahmadu Bello University Teaching Hospital (ABUTH).

Settings and design: This was a cross-sectional descriptive study conducted in ABUTH.

Subjects and methods: The data were abstracted from the case notes of neonates admitted from May 2017 to May 2018. A pretested pro forma was used to abstract the data.

Statistical analysis used: Odds ratios and multivariate logistic regression were used to determine the factors associated with neonatal sepsis among the study population.

Results: The prevalence of neonatal sepsis was 37.6%. Escherichia coli was the most commonly isolated organism. Neonates 0-7 days of age were 2.8 times less likely to develop neonatal sepsis than older neonates. Babies born with an Apgar score of <6 within the 1st min were 2.4 times more likely to develop neonatal sepsis than those whose Apgar score was higher. Neonates of mothers who had urinary tract infection during pregnancy were 2.3 times more likely to have had sepsis and those whose mothers had premature rupture of membranes were 4.6 times more likely.

Conclusions: The prevalence of neonatal sepsis was high among the neonates studied. Neonatal and maternal factors were associated with sepsis in the neonates. These findings provide guidelines for the selection of empirical antimicrobial agents in the study site and suggest that a continued periodic evaluation is needed to anticipate the development of neonatal sepsis among neonates admitted.

Keywords: Empirical antimicrobials; neonatal; predictors; septicemia; tertiary.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Causative organisms responsible for neonatal sepsis among study neonates in the Ahmadu Bello University Teaching Hospital
See this image and copyright information in PMC

References

    1. Edmond K, Zaidi A. New approaches to preventing, diagnosing, and treating neonatal sepsis. PLoS Med. 2010;7:e1000213. - PMC - PubMed
    1. Neonatal Sepsis in Newborn, AIIMS Protocol in India. 2014. [Last cited 2019 Jun 15]. Available from: http://www.newbornwhocc.org/2014_pdf/Neonatal%20sepsis%202014.pdf .
    1. Sanghvi KP, Tudehope DI. Neonatal bacterial sepsis in a neonatal intensive care unit: A 5 year analysis. J Paediatr Child Health. 1996;32:333–8. - PubMed
    1. West B, Tabansi P. Prevalence of neonatal septicaemia in the University of port harcourt teaching hospital, Nigeria. Niger J Paediatr. 2013;41:33.
    1. Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD. Early-onset neonatal sepsis. Clin Microbiol Rev. 2014;27:21–47. - PMC - PubMed