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. 2020 Jun 29:2020:3082318.
doi: 10.1155/2020/3082318. eCollection 2020.

The Association between Serum Uric Acid and Bone Mineral Density in Older Adults

Xiaocong Yao  1 , Lin Chen  2 , Huihui Xu  3   4 , Zhongxin Zhu  1   3   4
Affiliations

The Association between Serum Uric Acid and Bone Mineral Density in Older Adults

Xiaocong Yao et al. Int J Endocrinol. .

Abstract

Objectives: Uric acid has been found to be potentially protective in bone metabolism. We investigated the relationship between serum uric acid (sUA) and lumbar bone mineral density (BMD) among 4156 participants aged 60 years and over from the National Health and Nutrition Examination Survey (NHANES).

Methods: To estimate the association between sUA and lumbar BMD, multivariate logistic regression analyses were conducted. Fitted smoothing curves and generalized additive models were also performed.

Results: We found sUA positively correlated with lumbar BMD after adjusting for other confounders. On subgroup analyses, stratified by sex and race/ethnicity, the positive correlation of sUA with lumbar BMD remained in both men and women, as well as in whites and Mexican Americans, but not in blacks. In blacks, the association of sUA with lumbar BMD was an inverted U-shaped curve (inflection point: 7.5 mg/dL).

Conclusions: Our study revealed a positive relationship between sUA and lumbar BMD among most old adults. This association followed an inverted U-shaped curve among blacks.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
The association between serum uric acid and lumbar bone mineral density. (a) Each black point represents a sample. (b) Solid rad line represents the smooth curve fit between variables. Blue bands represent the 95% of confidence interval from the fit. Age, sex, race/ethnicity, waist circumference, education, income poverty ratio, physical activity, smoking behavior, alcohol consumption, blood urea nitrogen, C-reactive protein, total protein, total cholesterol, serum phosphorus, serum calcium, and calcium supplementation use were adjusted.
Figure 2
Figure 2
The association between serum uric acid and lumbar bone mineral density stratified by sex. Age, race/ethnicity, body mass index, education, income poverty ratio, physical activity, smoking behavior, alcohol consumption, blood urea nitrogen, C-reactive protein, total protein, total cholesterol, serum phosphorus, serum calcium, and calcium supplementation use were adjusted.
Figure 3
Figure 3
The association between uric acid and lumbar bone mineral density stratified by race/ethnicity. Age, sex, body mass index, education, income poverty ratio, physical activity, smoking behavior, alcohol consumption, blood urea nitrogen, C-reactive protein, total protein, total cholesterol, serum phosphorus, serum calcium, and calcium supplementation use were adjusted.
See this image and copyright information in PMC

References

    1. Wang P., Abdin E., Shafie S., Chong S. A., Vaingankar J. A., Subramaniam M. Estimation of prevalence of osteoporosis using OSTA and its correlation with sociodemographic factors, disability and comorbidities. International Journal of Environmental Research and Public Health. 2019;16 doi: 10.3390/ijerph16132338. - DOI - PMC - PubMed
    1. Ström O., Borgström F., Kanis J. A., et al. Osteoporosis: burden, health care provision and opportunities in the EU. Archives of Osteoporosis. 2011;6(1-2):59–155. doi: 10.1007/s11657-011-0060-1. - DOI - PubMed
    1. Perez-Ruiz F., Dalbeth N., Bardin T. A review of uric acid, crystal deposition disease, and gout. Advances in Therapy. 2015;32(1):31–41. doi: 10.1007/s12325-014-0175-z. - DOI - PMC - PubMed
    1. Taghizadeh N., Vonk J. M., Boezen H. M. Serum uric acid levels and cancer mortality risk among males in a large general population-based cohort study. Cancer Causes & Control. 2014;25(8):1075–1080. doi: 10.1007/s10552-014-0408-0. - DOI - PMC - PubMed
    1. Tana C., Ticinesi A., Prati B., Nouvenne A., Meschi T. Uric acid and cognitive function in older individuals. Nutrients. 2018;10 doi: 10.3390/nu10080975. - DOI - PMC - PubMed

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