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Review
. 2020 Jun 26:7:109.
doi: 10.3389/fmolb.2020.00109. eCollection 2020.

Circular RNAs in Blood Malignancies

Olivia Perez de Acha  1 , Martina Rossi  1 , Myriam Gorospe  1
Affiliations
Review

Circular RNAs in Blood Malignancies

Olivia Perez de Acha et al. Front Mol Biosci. .

Abstract

Circular (circ)RNAs influence a wide range of biological processes at least in part by interacting with proteins and microRNAs. CircRNAs expressed in the hematopoietic compartment have been increasingly recognized as modulators of physiological and pathological features of hematopoetic stem cell (HSC)-derived populations. In particular, several circRNAs were found to enhance or suppress tumor progression in blood malignancies such as leukemias and lymphomas. Moreover, numerous circRNAs have been proposed to help confer resistance to the conventional treatments used in hematopoietic cancers. Here, we review the most important circRNAs described thus far in acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), lymphomas, and multiple myeloma (MM). We discuss the usefulness of circRNAs as diagnostic and prognostic markers and their potential value as therapeutic targets.

Keywords: blood malignancies; circular RNAs; leukemias; lymphomas; non-coding RNA.

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Figures

Figure 1
Figure 1
Schematic of hematopoiesis depicting the developmental cell types giving rise to the major leukemias and lymphomas. AML, CML, ALL, CLL, Lymphomas, and MM described in the text are represented. Gray boxes, the main circRNAs associated with each malignancy are indicated in red (upregulated in malignancy) or green (downregulated in malignancy).
See this image and copyright information in PMC

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