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. 2020 Aug;14(12):1091-1097.
doi: 10.2217/bmm-2020-0309. Epub 2020 Jul 17.

The association between biomarkers and clinical outcomes in novel coronavirus pneumonia in a US cohort

Shant Ayanian  1 , Juan Reyes  1 , Lei Lynn  1 , Karolyn Teufel  1
Affiliations

The association between biomarkers and clinical outcomes in novel coronavirus pneumonia in a US cohort

Shant Ayanian et al. Biomark Med. 2020 Aug.

Abstract

Aim: To describe the association between D-dimer, CRP, IL-6, ferritin, LDH and the clinical outcomes in a cohort of 299 COVID-19 patients treated on the inpatient medical service at a university hospital in the District of Columbia (DC, USA). Methodology & results: In this retrospective study, we included all laboratory confirmed COVID-19 adults admitted to the inpatient medicine service at the George Washington University Hospital between 12 March 2020 and 9 May 2020. We analyzed the association of biomarkers on intensive care unit transfer, intubation and mortality. Threshold values for all biomarkers were found to be statistically significant and independently associated with higher odds of clinical deterioration and death. Conclusion: Laboratory markers of inflammation and coagulopathy can help clinicians identify patients who are at high risk for clinical deterioration in COVID-19.

Keywords: COVID-19; CRP; D-dimer; LDH; biomarkers; ferritin; infectious diseases; interleukin-6.

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Figures

Figure 1.
Figure 1.. Whisker plots for different biomarkers and outcomes.
ICU: Intensive care unit.
See this image and copyright information in PMC

References

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