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. 2020 Jul 16;20(1):519.
doi: 10.1186/s12879-020-05242-w.

Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of COVID-19 in Wuhan, China: a descriptive study

Dan Wang  1 , Ruifang Li  1 , Juan Wang  2 , Qunqun Jiang  3 , Chang Gao  1 , Juan Yang  1 , Lintong Ge  1 , Qing Hu  4
Affiliations

Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of COVID-19 in Wuhan, China: a descriptive study

Dan Wang et al. BMC Infect Dis. .

Abstract

Background: Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan and has quickly spread across the world. The mortality rate in critically ill patients with COVID-19 is high. This study analyzed clinical and biochemical parameters between mild and severe patients, helping to identify severe or critical patients early.

Methods: In this single center, cross-sectional study, 143 patients were included and divided to mild/moderate and sever/critical groups. Correlation between the disease criticality and clinical features and peripheral blood biochemical markers was analyzed. Cut-off values for critically ill patients were speculated through the ROC curve.

Results: Significantly, disease severity was associated with age (r = 0.458, P < 0.001), comorbidities (r = 0.445, P < 0.001), white cell count (r = 0.229, P = 0.006), neutrophil count (r = 0.238, P = 0.004), lymphocyte count (r = - 0.295, P < 0.001), albumin (r = - 0.603, P < 0.001), high-density lipoprotein cholesterol (r = - 0.362, P < 0.001), serum potassium (r = - 0.237, P = 0.004), plasma glucose (r = 0.383, P < 0.001), total bilirubin (r = 0.340, P < 0.001), serum amyloid A (r = 0.58, P < 0.001), procalcitonin (r = 0.345, P < 0.001), C-reactive protein (r = 0.477, P < 0.001), lactate dehydrogenase (r = 0.548, P < 0.001), aspartate aminotransferase (r = 0.342, P < 0.001), alanine aminotransferase (r = 0.264, P = 0.001), erythrocyte sedimentation rate (r = 0.284, P = 0.001) and D-dimer (r = 0.477, P < 0.001) .

Conclusions: With the following parameters such as age > 52 years, C-reactive protein > 64.79 mg/L, lactate dehydrogenase > 245 U/L, D-dimer > 0.96 μg/mL, serum amyloid A > 100.02 mg/L, or albumin < 36 g/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. Lymphocyte count, serum potassium, high-density lipoprotein cholesterol and procalcitonin may also be a prognostic indicator.

Keywords: COVID-19; Correlation analysis; Prognostic indicator; SARS-CoV-2.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
A patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. a Ground glass shadow in multiple lobes and segments of bilateral lungs, and the lesions were adjacent to the pleura (Illness Day 7, Hospital Day 0). b Ground glass shadow expanding and consolidation in bilateral lung (Illness Day 12, Hospital Day 5). c Ground glass shadow absorption and reduced consolidation area (Illness Day 18, Hospital Day 11). d Lesion dissipation (Illness Day 24, Hospital Day 17)
Fig. 2
Fig. 2
ROC curve of indicators between mild/moderate and severe/critical. a age; b LDH; c D-dimer; d SAA; e Albumin; f CRP
Fig. 3
Fig. 3
ROC curve of combined indicators for the speculation of disease severity
See this image and copyright information in PMC

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