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Randomized Controlled Trial
. 2020 Dec;43(12):1392-1402.
doi: 10.1038/s41440-020-0509-y. Epub 2020 Jul 16.

Association of self-reported sleep duration and quality with BaPWV levels in hypertensive patients

Huan Hu  1   2 , Huan Li  3 , Xiao Huang  1   2 , Huihui Bao  1   2 , Yun Song  4   5 , Binyan Wang  5   6 , Chengzhang Liu  6 , Richard Xu  7 , Lishun Liu  4 , Xiaobin Wang  8 , Yong Huo  9 , Xiping Xu  3   4 , Xiaoshu Cheng  1   2 , Xianhui Qin  10   11 , Ping Li  12   13
Affiliations
Randomized Controlled Trial

Association of self-reported sleep duration and quality with BaPWV levels in hypertensive patients

Huan Hu et al. Hypertens Res. 2020 Dec.

Abstract

The association between sleep conditions and arterial stiffness remains inconclusive. We aimed to investigate the relationship of sleep duration and quality with brachial-ankle pulse-wave velocity (baPWV) in hypertensive patients. A total of 14,485 hypertensive adults were included in this cross-sectional analysis. Information about sleep duration and quality was obtained via questionnaire. A baPWV level ≥1800 cm/s was defined as indicative of arterial stiffness. Compared with participants with a sleep duration <8 h per day, participants with a sleep duration ≥8 h per day had a significantly higher baPWV level (β = 13.7 cm/s; 95% CI: 3.9, 23.5) and a nonsignificantly higher prevalence of arterial stiffness (39.7% vs. 33.0%; OR, 1.08; 95% CI: 0.99-1.19). Similarly, compared with participants with good or medium sleep quality, participants with poor sleep quality had a significantly higher baPWV level (β = 16.3 cm/s; 95% CI: 0.1, 32.6) and a nonsignificantly greater prevalence of arterial stiffness (36.6% vs. 35.3%; OR, 1.13; 95% CI: 0.97-1.32). When sleep duration and quality were examined jointly, participants with a sleep duration ≥8 h and/or poor sleep quality had a significantly higher baPWV level (β = 14.4 cm/s; 95% CI: 5.3, 23.4) and a greater prevalence of arterial stiffness (38.8% vs. 32.7%; OR, 1.10; 95% CI: 1.01-1.20) than those with a sleep duration <8 h and good/medium sleep quality. In summary, among hypertensive patients, a longer sleep duration (≥8 h per day) and poor sleep quality were associated with higher baPWV levels and a higher prevalence of arterial stiffness.

Keywords: Hypertension · Sleep duration · Sleep quality · Arterial stiffness · Brachial-ankle pulse-wave velocity.

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Conflict of interest statement

All authors have completed the ICMJE uniform disclosure form and have declared the following: XX reports grants from the National Key Research and Development Program [2016YFE0205400, 2018ZX09739, 2018ZX09301034003]; the Science and Technology Planning Project of Guangzhou, China [201707020010]; the Science, Technology and Innovation Committee of Shenzhen [JSGG20170412155639040, GJHS20170314114526143, JSGG20180703155802047]; and the Economic, Trade and Information Commission of Shenzhen Municipality [20170505161556110, 20170505160926390]. XQ reports grants from the National Natural Science Foundation of China [81730019, 81973133] and Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University [2017J009]. PL reports grants from the National Natural Science Foundation of China [81560079, 81860058], Major Projects of the Science and Technology Department, Jiangxi [20152ACB20022], the Funding Scheme for Academic and Technical Leaders of Major Disciplines, Jiangxi [20172BCB22027], and the Special Funds for Guiding Local Scientific and Technological Development by the Central Government of China (S2019CXSFG0016). XH reports grants from the National Natural Science Foundation of China [81960074, 81500233]; Jiangxi Outstanding Person Foundation [20192BCBL23024]; and Major Projects of the Science and Technology Department, Jiangxi [20171BAB205008]. No other financial or nonfinancial disclosures were reported.

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