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. 2020 Oct:281:103494.
doi: 10.1016/j.resp.2020.103494. Epub 2020 Jul 15.

High altitude reduces infection rate of COVID-19 but not case-fatality rate

Jose Segovia-Juarez  1 , Jesús M Castagnetto  2 , Gustavo F Gonzales  3
Affiliations

High altitude reduces infection rate of COVID-19 but not case-fatality rate

Jose Segovia-Juarez et al. Respir Physiol Neurobiol. 2020 Oct.

Abstract

Coronavirus disease 19 (COVID-19) is a pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). It is suggested that life at high altitude may reduce COVID-19 infections and case-fatality rates (cases/deaths). We study data from Peru COVID-19 pandemics, which first case was recorded on March 6th, 2020. By June 13, 2020 there were 6498 deaths, and 224,132 SARS-CoV-2 positives. Using data from 185 capitals of provinces with altitudes ranging from 3 to 4342 m, we confirm previous reports that infection with COVID-19 at high altitude is reduced. However, case-fatality rate is not dependent of altitude. We have also presented first evidence that female protection towards death by COVID-19 is reduced as altitude of residence increases.

Keywords: Altitude; COVID-19; Fatality rate; Hypoxia.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Number of Cases (Log Positive counts/population density) according to altitude (meters) of residence in Peru: (A) All positive cases, (B) Male cases, (C) Female cases, (D) Male/female ratio.
Fig. 2
Fig. 2
Number of Deaths by COVID-19 (Log deaths/population density) according to altitude (meters) of residence in Peru. A) All deaths, (B) Male deaths, (C) Female deaths, (D) Male/female ratio.
Fig. 3
Fig. 3
Cumulative case-fatality rate by COVID-19 in Peru according to altitude of residence.
See this image and copyright information in PMC

Comment in

References

    1. Arias-Reyes C., Zubieta-DeUrioste N., Poma-Machicao L., Aliaga-Raduan F., Carvajal-Rodriguez F., Dutschmann M., Schneider-Gasser E.M., Zubieta-Calleja G., Soliz J. Does the pathogenesis of SARS-CoV-2 virus decrease at high-altitude? Respir. Physiol. Neurobiol. 2020;277:103443. [PMC free article] [PubMed] [Google Scholar] - PMC - PubMed
    1. Burtscher J., Burtscher M., Millet G.P. Caution is needed on the effect of altitude on the pathogenesis of SAR-CoV-2 virus [published online ahead of print, 2020 May 21] Respir. Physiol. Neurobiol. 2020;279 doi: 10.1016/j.resp.2020.103464. - DOI - PMC - PubMed
    1. CDC . 2019. Principles of Epidemiology in Public Health Practice. Third Edition. An Introduction to Applied Epidemiology and Biostatistics.https://www.cdc.gov/csels/dsepd/ss1978/lesson3/section3.html Retrieved from.
    1. Channappanavar R., Fett C., Mack M., Ten Eyck P.P., Meyerholz D.K., Perlman S. Sex-based differences in susceptibility to severe acute respiratory syndrome coronavirus infection. J. Immunol. 2017;198:4046–4053. - PMC - PubMed
    1. Debnath M., Banerjee M., Berk M. Genetic gateways to COVID-19 infection: implications for risk, severity, and outcomes [published online ahead of print, 2020 Jun 11] FASEB J. 2020 doi: 10.1096/fj.202001115R. - DOI - PMC - PubMed

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