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Review
. 2020 Oct;96(4):1069-1083.
doi: 10.1111/cbdd.13759. Epub 2020 Aug 24.

Review on druggable targets of key age-associated properties regulated by therapeutic agents

Ambili Unni P  1 , Sajitha Lulu Sudhakaran  1 , Girinath G Pillai  1   2
Affiliations
Review

Review on druggable targets of key age-associated properties regulated by therapeutic agents

Ambili Unni P et al. Chem Biol Drug Des. 2020 Oct.

Abstract

Aging is a biological process which accounts for the deterioration of effective physiological functions. The malfunctioning of vital organ systems leads to the onset of neurodegenerative, cardiovascular, and immunomodulatory diseases in the elder population. Age-dependent mitochondrial dysfunctions trigger the production of reactive oxygen species, which serve as a major contributing factor for the onset of age-associated diseases. The increasing burden of age-related pathologies explicates the relevance of identifying novel therapeutic agents with enhanced potency and bioavailability. Key information on the biological mechanisms of significant age-related diseases aids in understanding relevant druggable targets essential for the initiation and progression of the disease. This review provides detailed insights into the druggable targets of key anti-aging properties of therapeutic agents such as anti-oxidant, immunomodulation, cardioprotection, anti-melanogenic, and anti-elastase properties. This information aids in the development of novel therapeutic agents/ supplements with enhanced efficacy.

Keywords: Aging; age-associated diseases; druggable targets; mitochondrial dysfunctions; reactive oxygen species.

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References

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