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. 2020 Jul 17;20(1):666.
doi: 10.1186/s12885-020-07147-y.

A nomogram model to predict death rate among non-small cell lung cancer (NSCLC) patients with surgery in surveillance, epidemiology, and end results (SEER) database

Bo Jia  1 , Qiwen Zheng  2 , Jingjing Wang  1 , Hongyan Sun  3 , Jun Zhao  1 , Meina Wu  1 , Tongtong An  1 , Yuyan Wang  1 , Minglei Zhuo  1 , Jianjie Li  1 , Xue Yang  1 , Jia Zhong  1 , Hanxiao Chen  1 , Yujia Chi  1 , Xiaoyu Zhai  1 , Ziping Wang  4
Affiliations

A nomogram model to predict death rate among non-small cell lung cancer (NSCLC) patients with surgery in surveillance, epidemiology, and end results (SEER) database

Bo Jia et al. BMC Cancer. .

Abstract

Background: This study aimed to establish a novel nomogram prognostic model to predict death probability for non-small cell lung cancer (NSCLC) patients who received surgery..

Methods: We collected data from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute in the United States. A nomogram prognostic model was constructed to predict mortality of NSCLC patients who received surgery.

Results: A total of 44,880 NSCLC patients who received surgery from 2004 to 2014 were included in this study. Gender, ethnicity, tumor anatomic sites, histologic subtype, tumor differentiation, clinical stage, tumor size, tumor extent, lymph node stage, examined lymph node, positive lymph node, type of surgery showed significant associations with lung cancer related death rate (P < 0.001). Patients who received chemotherapy and radiotherapy had significant higher lung cancer related death rate but were associated with significant lower non-cancer related mortality (P<0.001). A nomogram model was established based on multivariate models of training data set. In the validation cohort, the unadjusted C-index was 0.73 (95% CI, 0.72-0.74), 0.71 (95% CI, 0.66-0.75) and 0.69 (95% CI, 0.68-0.70) for lung cancer related death, other cancer related death and non-cancer related death.

Conclusions: A prognostic nomogram model was constructed to give information about the risk of death for NSCLC patients who received surgery.

Keywords: NSCLC; Nomogram; Prognosis; SEER; Surgery.

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Conflict of interest statement

The Authors Declared No Potential Conflicts of Interest.

Figures

Fig. 1
Fig. 1
Flow chart of patients’ selection
Fig. 2
Fig. 2
Nomogram model to predict 5- and 10-year (a) lung cancer, related (b) other cancer related, and (c) non-cancer related death rate in resected NSCLC patients. Gender: F, female; M, male; Ethnicity: B, black; O, other; W, white; A, asian; Surgery: L, lobectomy; P, pneumonectomy; S, sub-lobar; Differentiation: W, well differentiated; M, moderately differentiated; P, poorly differentiated; U, undifferentiated; Histology: ADC, adenocarcinoma; ASDC, adenosquamous carcinoma; BAC, bronchoalveolar carcinoma; SCC, squamous cell carcinoma; LCC, large cell carcinoma; O, other; U, unspecified NSCLC; Tumor extension: D, distant; L, localized; R, regional; Chemotherapy: N, none; Y, received chemotherapy; Radiotherapy: N, none; Y, received radiotherapy
Fig. 3
Fig. 3
Nomogram calibration plot in the validation set. The x-axis represents the mean predicted death probability. The y-axis represents actual death rate. The solid line represents equality between the predicted and actual probability
See this image and copyright information in PMC

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