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Comment
. 2020 Aug 4;117(31):18151-18153.
doi: 10.1073/pnas.2011909117. Epub 2020 Jul 17.

Maladaptive response of arterial myocytes to chronic exposure to Ca2+ channel blockers

Samantha C O'Dwyer  1 , Manuel F Navedo  2 , L F Santana  3
Affiliations
Comment

Maladaptive response of arterial myocytes to chronic exposure to Ca2+ channel blockers

Samantha C O'Dwyer et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Response of contractile and synthetic smooth muscle to hypertension and L-type Ca2+ blockers. (A) During hypertension, contractile myocytes shorten in response to increased CaV1.2 channel activity, whereas synthetic myocytes experience a reduction in contractile proteins and increase in SOCE machinery. L-type Ca2+ blockers elicit a decrease in CaV1.2 influx, promoting relaxation and vasodilation. Synthetic myocytes see an increase in SOCE, proliferation, and migration, resulting in hyperplasia and increased incidence of heart failure. (B) L-type Ca2+ channel blockers stimulate the assembly of the STIM1/ORAI complexes via an unknown mechanism. The STIM1/ORAI complex promotes SOCE independent of S/ER Ca2+ content or CaV1.2 function. SOCE increases [Ca2+]i and promotes proliferation and migration of arterial smooth muscle cells, which is linked to heart failure.
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