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. 2020 Dec;70(3):629-634.
doi: 10.1007/s12020-020-02420-3. Epub 2020 Jul 17.

The 2039 A/G FSH receptor gene polymorphism influences glucose metabolism in healthy men

Rossella Cannarella  1 , Nicolò Musso  2 , Rosita A Condorelli  1 , Marco Musmeci  1 , Stefania Stefani  2 , Antonio Aversa  3 , Sandro La Vignera  1 , Aldo E Calogero  4
Affiliations

The 2039 A/G FSH receptor gene polymorphism influences glucose metabolism in healthy men

Rossella Cannarella et al. Endocrine. 2020 Dec.

Abstract

Objective: To assess the role of c. 2039 A/G (p. Asp680Ser) (rs6166) and c. -29 G/A (rs1394205) follicle-stimulating hormone receptor (FSHR) gene single nucleotide polymorphisms (SNPs) in a cohort of healthy men.

Methods: One-hundred twenty-seven healthy men underwent evaluation of the anthropometric parameters, assessment of metabolic and lipid profile, measurement FSH serum levels, and genotyping of both the aforementioned FSHR SNPs. Data grouped according to the FSHR rs6166 or rs1394205 genotypes underwent to statistical analysis.

Main results: The three groups of men for each FSHR SNP did not differ statistically significantly for body mass index and serum FSH levels. As for FSHR rs6166 SNP, glucose levels were significantly lower in men with the GG genotype compared with those with the AA genotype. Men with AG had lower insulin levels and HOMA index values compared with those carrying the genotype AA (p < 0.05). The GG group showed a negative correlation between serum FSH levels and insulin and between serum FSH levels and HOMA index (p < 0.05). In contrast, men grouped according to the FSHR rs1394205 genotype showed no significant difference in blood glucose, serum insulin levels, and HOMA index. The AG group showed a negative correlation between FSH insulin and between serum FSH levels and HOMA index (p < 0.05).

Conclusions: Men with the genotype GG of the FSHR rs6166 SNP have lower blood glucose levels than those with the AA genotype. Their FSH levels inversely correlated with insulin and HOMA index. In contrast, the genotype FSHR rs6166 A/G did not reveal any role of FSH on glucose metabolism in healthy men. The inverse relationship between FSH and insulin or HOMA index in the group with the genotype GG of the FSHR rs6166 SNP suggests a possible cross-talk between FSH and insulin.

Keywords: 2039 A/G FSHR; FSH; FSHR polymorphism; Glucose; Insulin; Metabolism.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Glycaemia, insulin, and HOMA index classified according to the rs1394205 FSHR genotype. No significant difference was found in AA, AG, and GG groups for glycaemia (a), insulin (b), and HOMA index (c)
See this image and copyright information in PMC

References

    1. Gromoll J, Pekel E, Nieschlag E. The structure and organization of the human follicle-stimulating hormone receptor (FSHR) gene. Genomics. 1996;35:308–311. doi: 10.1006/geno.1996.0361. - DOI - PubMed
    1. Casarini L, Moriondo V, Marino M, Adversi F, Capodanno F, Grisolia C, La Marca A, La Sala GB, Simoni M. FSHR polymorphism p.N680S mediates different responses to FSH in vitro. Mol. Cell. Endocrinol. 2014;393:83–91. doi: 10.1016/j.mce.2014.06.013. - DOI - PubMed
    1. Nakayama T, Kuroi N, Sano M, Tabara Y, Katsuya T, Ogihara T, Makita Y, Hata A, Yamada M, Takahashi N, Hirawa N, Umemura S, Miki T, Soma M. Mutation of the follicle-stimulating hormone receptor gene 5’-untranslated region associated with female hypertension. Hypertension. 2006;48:512–518. doi: 10.1161/01.HYP.0000233877.84343.d7. - DOI - PubMed
    1. Ferlin A, Vinanzi C, Selice R, Garolla A, Frigo AC, Foresta C. Toward a pharmacogenetic approach to male infertility: polymorphism of follicle-stimulating hormone b-subunit promoter. Fertil. Steril. 2011;96:1344–1349. doi: 10.1016/j.fertnstert.2011.09.034. - DOI - PubMed
    1. Tüttelmann F, Laan M, Grigorova M, Punab M, Sõber S, Gromoll J. Combined effects of the variants FSHB -211G>T and FSHR 2039A>G on male reproductive parameters. J. Clin. Endocrinol. Metab. 2012;97(10):3639–3647. doi: 10.1210/jc.2012-1761. - DOI - PubMed

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