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. 2020 Dec;22(6):e13416.
doi: 10.1111/tid.13416. Epub 2020 Aug 2.

Kidney transplantation during coronavirus 2019 pandemic at a large hospital in Miami

Aditya Chandorkar  1 , Ana Coro  1   2 , Yoichiro Natori  1   2 , Shweta Anjan  1   2 , Lilian M Abbo  1   2 , Giselle Guerra  2   3 , Adela D Mattiazzi  2   3 , Lumen A Mendez-Castaner  2   3 , Michele I Morris  1 , Jose F Camargo  1 , Rodrigo Vianna  2   4 , Jacques Simkins  1   2
Affiliations

Kidney transplantation during coronavirus 2019 pandemic at a large hospital in Miami

Aditya Chandorkar et al. Transpl Infect Dis. 2020 Dec.

Abstract

Background: Coronavirus 2019 (COVID-19) pandemic has resulted in more than 350 000 deaths worldwide. The number of kidney transplants has declined during the pandemic. We describe our deceased donor kidney transplantation (DDKT) experience during the pandemic.

Methods: A retrospective study was conducted to evaluate the safety of DDKT during the COVID-19 pandemic. Multiple preventive measures were implemented. Adult patients that underwent DDKT from 3/1/20 to 4/30/20 were included. COVID-19 clinical manifestations from donors and recipients, and post-transplant outcomes (COVID-19 infections, readmissions, allograft rejection, and mortality) were obtained. The kidney transplant (KT) recipients were followed until 5/31/20.

Results: Seventy-six patients received kidneys from 57 donors. Fever, dyspnea, and cough were reported in 1, 2, and 1 donor, respectively. Thirty-eight (66.6%) donors were tested for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) prior to donation (mainly by nasopharyngeal or bronchoalveolar lavage polymerase chain reaction [PCR]) and 36 (47.3%) KT recipients were tested at the time of DDKT by nasopharyngeal PCR; all of these were negative. Our recipients were followed for a median of 63 (range: 33-91) days. A total of 42 (55.3%) recipients were tested post-transplant for SARS-CoV2 by nasopharyngeal PCR including 12 patients that became symptomatic; all tests were negative except for one that was inconclusive, but it was repeated and came back negative. Forty (52.6%) KT recipients were readmitted, and 7 (9.2%) had biopsy-proven rejection during the follow-up. None of the KT recipients transplanted during this period died.

Conclusions: Our cohort demonstrated that DDKT can be safely performed during the COVID-19 pandemic when preventive measures are implemented.

Keywords: COVID-19; PCR; SARS-CoV2; kidney transplant; safety.

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References

    1. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497‐506. - PMC - PubMed
    1. Helmy YA, Fawzy M, Elaswad A, Sobieh A, Kenney SP, Shehata AA. The COVID‐19 pandemic: a comprehensive review of taxonomy, genetics, epidemiology, diagnosis, treatment, and control. J Clin Med. 2020;9:1225. - PMC - PubMed
    1. World Health Organization . Rolling Updates on Coronavirus Disease (COVID‐19). https://www.who.int/emergencies/diseases/novel‐coronavirus‐2019/events‐a.... Accessed July 3, 2020.
    1. COVID‐19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). https://systems.jhu.edu/. Accessed July 3, 2020.
    1. Florida's COVID‐19 Data and Surveillance Dashboard. Florida Department of Health, Division of Disease Control and Health Protection . https://experience.arcgis.com/experience/96dd742462124fa0b38ddedb9b25e429 Accessed July 3, 2020.

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