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. 2020 Nov;159(5):1955-1957.e2.
doi: 10.1053/j.gastro.2020.07.012. Epub 2020 Jul 15.

Postprandial Chylomicron Output and Transport Through Intestinal Lymphatics Are Not Impaired in Active Crohn's Disease

Li-Hao Huang  1 , Parakkal Deepak  2 , Matthew A Ciorba  2 , Bettina Mittendorfer  3 , Bruce W Patterson  3 , Gwendalyn J Randolph  4
Affiliations

Postprandial Chylomicron Output and Transport Through Intestinal Lymphatics Are Not Impaired in Active Crohn's Disease

Li-Hao Huang et al. Gastroenterology. 2020 Nov.
No abstract available

Keywords: Chylomicron; Enterocyte; Hormone; Lipoprotein; Trafficking; Transport.

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Conflict of interest statement

No authors declare a financial conflict of interest with this work.

Figures

Figure 1.
Figure 1.
A) Chylomicron triglycerides (TG) derived from the test meal in all control versus all CD participants. B) % of test meal 13C-oleate tracer expired in breath over the 6 h study. Not all participants were analyzed due to equipment failure for a period of the study. C) Chylomicron-TG fractional clearance rate (pools/hr) derived from the monoexponential slope of chylomicron-TG glycerol after bolus injection of 2H5-glycerol. D) Chylomicron-TG derived from nonmeal sources in all control versus all CD participants. E) Data from panel D replotted to separately display the 8 CD participants taking TNFi adalimumab in the study (square symbols) versus all other CD participants not taking TNFi (diamond symbols) or control participants. F) Plasma GIP in the same groupings as shown in panel E. G) Immunoblot of the chylomicron fraction for apoB isoforms. H) A ratio of postprandial triglyceride (mg/l) to apoB48 (microgram/ml) concentration over the time course for each subject in the same experimental groupings as those in panels E and F, with baseline values subtracted to focus on the postprandial response. I) Analysis of mean chylomicron/chylomicron remnant size in the chylomicron fraction of plasma at the 90-minute time point, examining all CD + TNFi participants and 7 randomly selected control participants at the same time point. In all panels, statistical analyses were done using nonparametric tests; Mann U Whitney tests for panels B, C, I. Friedman tests for panels A, D, E, F, H. *, p <0.05; **, p<0.01; ***, p<0.001; ****, p<0.0001. The absence of a symbol for statistical significance indicates that statistically significant differences were not found.
See this image and copyright information in PMC

Comment in

  • Lymphatic-dependent Transport of Chylomicrons in Inflammatory Bowel Disease.
    Tian Y, Zuo L. Tian Y, et al. Gastroenterology. 2021 May;160(6):2199-2200. doi: 10.1053/j.gastro.2020.12.041. Epub 2020 Dec 30. Gastroenterology. 2021. PMID: 33385432 No abstract available.
  • Reply.
    Randolph GJ, Czepielewski RS. Randolph GJ, et al. Gastroenterology. 2021 May;160(6):2200-2201. doi: 10.1053/j.gastro.2021.01.202. Epub 2021 Jan 21. Gastroenterology. 2021. PMID: 33484689 No abstract available.

References

    1. Van Kruiningen HJ, et al. Gut 2008; 57:1–4. - PubMed
    1. Xiao C, et al. Cell Mol Gastroenterol Hepatol. 2019;7:487–501. - PMC - PubMed
    1. Wang B, et al. Cell Metabolism 2016; 23:492–504. - PMC - PubMed
    1. Uchiyama K, et al. J. Immunol. Res 2018; 7270486. - PMC - PubMed
    1. Haberman Y, et al. J Clin Invest 2015; 124:3617–3633. - PMC - PubMed

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