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Meta-Analysis
. 2020 Oct:147:104390.
doi: 10.1016/j.micpath.2020.104390. Epub 2020 Jul 15.

Clinical characteristics, laboratory findings, radiographic signs and outcomes of 61,742 patients with confirmed COVID-19 infection: A systematic review and meta-analysis

Ali Pormohammad  1 , Saied Ghorbani  2 , Behzad Baradaran  3 , Alireza Khatami  2 , Raymond J Turner  4 , Mohammad Ali Mansournia  5 , Demetrios N Kyriacou  6 , Juan-Pablo Idrovo  7 , Nathan C Bahr  8
Affiliations
Meta-Analysis

Clinical characteristics, laboratory findings, radiographic signs and outcomes of 61,742 patients with confirmed COVID-19 infection: A systematic review and meta-analysis

Ali Pormohammad et al. Microb Pathog. 2020 Oct.

Abstract

Introduction: In the current time where we face a COVID-19 pandemic, there is no vaccine or effective treatment at this time. Therefore, the prevention of COVID-19 and the rapid diagnosis of infected patients is crucial.

Method: We searched all relevant literature published up to February 28, 2020. We used Random-effect models to analyze the appropriateness of the pooled results.

Result: Eighty studies were included in the meta-analysis, including 61,742 patients with confirmed COVID-19 infection. 62.5% (95% CI 54.5-79, p < 0.001) of patients had a history of recent travel endemic area or contact with them. The most common symptoms among COVID-19 infected patients were fever 87% (95% CI 73-93, p < 0.001), and cough 68% (95% CI 55.5-74, p < 0.001)), respectively. The laboratory analysis showed that thrombocytosis was present in 61% (95% CI 41-78, p < 0.001) CRP was elevated in 79% (95% CI 65-91, p < 0.001), and lymphopenia in 57.5% (95% CI 42-79, p < 0.001). The most common radiographic signs were bilateral involvement in 81% (95% CI 62.5-87, p < 0.001), consolidation in 73.5% (95% CI 50.5-91, p < 0.001), and ground-glass opacity 73.5% (95% CI 40-90, p < 0.001) of patients. Case fatality rate (CFR) in <15 years old was 0.6%, in >50 years old was 39.5%, and in all range group was 6%.

Conclusions: Fever and cough are the most common symptoms of COVID-19 infection in the literature published to date. Thombocytosis, lymphopenia, and increased CRP were common lab findings although most patients included in the overall analysis did not have laboratory values reported. Among Chinese patients with COVID-19, rates of hospitalization, critical condition, and hospitalization were high in this study, but these findings may be biased by reporting only confirmed cases.

Keywords: COVID-19; Coronavirus; SARS-CoV-2; Severe acute respiratory syndrome coronavirus; meta-Analysis.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig. 1
Fig. 1
Flow Diagram of Literature Search and Study Selection (PRISMA flow chart).
Fig. 2
Fig. 2
Forest plot of the meta-analysis on clinical presentation of case fatality rate (CFR) in different age groups of confirmed COVID-19 cases.
Fig. 3
Fig. 3
Forest plot of the meta-analysis on clinical presentation of case fatality rate (CFR) in all age groups of confirmed COVID-19 cases.
See this image and copyright information in PMC

References

    1. Zhu N., Zhang D., Wang W., Li X., Yang B., Song J. A novel coronavirus from patients with pneumonia in China. N. Engl. J. Med. 2019 2020. - PMC - PubMed
    1. Chan J.F.-W., Yuan S., Kok K.-H., To K.K.-W., Chu H., Yang J. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020 - PMC - PubMed
    1. Bernheim A., Mei X., Huang M., Yang Y., Fayad Z.A., Zhang N. Chest CT findings in coronavirus disease-19 (COVID-19): relationship to duration of infection. Radiology. 2020:200463. - PMC - PubMed
    1. Who. Rational Use of Personal Protective Equipment for Coronavirus Disease 2019 (COVID-19) 2020, Feb 27.
    1. Lam W., Zhong N., Tan W. Overview on SARS in Asia and the world. Respirology. 2003;8:S2–S5. - PMC - PubMed