Covid-19 infection and the host genetic predisposition: does it exist?

doi:10.33549/physiolres.934504

Review

. 2020 Jul 16;69(3):511-514.

doi: 10.33549/physiolres.934504.

Covid-19 infection and the host genetic predisposition: does it exist?

A Vašků¹

Affiliations

PMID: 32682363
PMCID: PMC8648312
DOI: 10.33549/physiolres.934504

Review

Covid-19 infection and the host genetic predisposition: does it exist?

A Vašků. Physiol Res. 2020.

. 2020 Jul 16;69(3):511-514.

doi: 10.33549/physiolres.934504.

Author

A Vašků¹

Affiliation

¹ Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. avasku@med.muni.cz.

PMID: 32682363
PMCID: PMC8648312
DOI: 10.33549/physiolres.934504

Abstract

Knowledge of genomic interindividual variability could help us to explain why different manifestation of clinical severity of Covid-19 infection as well as modified pharmacogenetic relations can be expected during this pandemic condition.

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Conflict of interest statement

Conflict of interest

There is no conflict of interest.

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References

1. ALEKSOVA A, FERRO F, GAGNO G, CAPPELLETTO C, SANTON D, ROSSI M, IPPOLITO G, ZUMLA A, BELTRAMI AP, SINAGRA G. COVID-19 and renin-angiotensin system inhibition: role of angiotensin converting enzyme 2 (ACE2) - is there any scientific evidence for controversy? J Intern Med. 2020 doi: 10.1111/joim.13101. - DOI - PMC - PubMed
1. BITKER L, BURRELL LM. Classic and nonclassic renin-angiotensin systems in the critically ill. Crit Care Clin. 2019;35:213–227. doi: 10.1016/j.ccc.2018.11.002. - DOI - PMC - PubMed
1. BOEHM M, NABEL EG. Angiotensin-converting enzyme 2 – a new cardiac regulator. New Engl J Med. 2002;347:1795–1797. doi: 10.1056/nejmcibr022472. - DOI - PubMed
1. CHIU RWK, TANG NLS, HUI DSC, CHUNG GTY, CHIM SSC, CHAN KCA, SUNG Y, CHAN LYS, TONG Y, LEE W, CHAN PKS, DENNIS LO YM. ACE2 gene polymorphisms do not affect outcome of severe acute respiratory syndrome. Clin Chem. 2004;50:1683–1689. doi: 10.1373/clinchem.2004.035436. - DOI - PMC - PubMed
1. CRACKOWER MA, SARAO R, OUDIT GY. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 2002;417:822–828. doi: 10.1038/nature00786. - DOI - PubMed

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[1] ALEKSOVA A, FERRO F, GAGNO G, CAPPELLETTO C, SANTON D, ROSSI M, IPPOLITO G, ZUMLA A, BELTRAMI AP, SINAGRA G. COVID-19 and renin-angiotensin system inhibition: role of angiotensin converting enzyme 2 (ACE2) - is there any scientific evidence for controversy? J Intern Med. 2020 doi: 10.1111/joim.13101. - DOI - PMC - PubMed

[2] ALEKSOVA A, FERRO F, GAGNO G, CAPPELLETTO C, SANTON D, ROSSI M, IPPOLITO G, ZUMLA A, BELTRAMI AP, SINAGRA G. COVID-19 and renin-angiotensin system inhibition: role of angiotensin converting enzyme 2 (ACE2) - is there any scientific evidence for controversy? J Intern Med. 2020 doi: 10.1111/joim.13101. - DOI - PMC - PubMed

[3] BITKER L, BURRELL LM. Classic and nonclassic renin-angiotensin systems in the critically ill. Crit Care Clin. 2019;35:213–227. doi: 10.1016/j.ccc.2018.11.002. - DOI - PMC - PubMed

[4] BITKER L, BURRELL LM. Classic and nonclassic renin-angiotensin systems in the critically ill. Crit Care Clin. 2019;35:213–227. doi: 10.1016/j.ccc.2018.11.002. - DOI - PMC - PubMed

[5] BOEHM M, NABEL EG. Angiotensin-converting enzyme 2 – a new cardiac regulator. New Engl J Med. 2002;347:1795–1797. doi: 10.1056/nejmcibr022472. - DOI - PubMed

[6] BOEHM M, NABEL EG. Angiotensin-converting enzyme 2 – a new cardiac regulator. New Engl J Med. 2002;347:1795–1797. doi: 10.1056/nejmcibr022472. - DOI - PubMed

[7] CHIU RWK, TANG NLS, HUI DSC, CHUNG GTY, CHIM SSC, CHAN KCA, SUNG Y, CHAN LYS, TONG Y, LEE W, CHAN PKS, DENNIS LO YM. ACE2 gene polymorphisms do not affect outcome of severe acute respiratory syndrome. Clin Chem. 2004;50:1683–1689. doi: 10.1373/clinchem.2004.035436. - DOI - PMC - PubMed

[8] CHIU RWK, TANG NLS, HUI DSC, CHUNG GTY, CHIM SSC, CHAN KCA, SUNG Y, CHAN LYS, TONG Y, LEE W, CHAN PKS, DENNIS LO YM. ACE2 gene polymorphisms do not affect outcome of severe acute respiratory syndrome. Clin Chem. 2004;50:1683–1689. doi: 10.1373/clinchem.2004.035436. - DOI - PMC - PubMed

[9] CRACKOWER MA, SARAO R, OUDIT GY. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 2002;417:822–828. doi: 10.1038/nature00786. - DOI - PubMed

[10] CRACKOWER MA, SARAO R, OUDIT GY. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 2002;417:822–828. doi: 10.1038/nature00786. - DOI - PubMed

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Covid-19 infection and the host genetic predisposition: does it exist?

Affiliation

Covid-19 infection and the host genetic predisposition: does it exist?

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Abstract

Conflict of interest statement

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Abstract

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