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Randomized Controlled Trial
. 2020 Sep 1;25(5):e644-e651.
doi: 10.4317/medoral.23661.

Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial

L-M Sáez-Alcaide, P Molinero-Mourelle, J González-Serrano, L Rubio-Alonso, M-M Bornstein, J López-Quiles
Randomized Controlled Trial

Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial

L-M Sáez-Alcaide et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Background: The aim of this study was to evaluate and compare the postoperative effect of a topic gel containing chlorhexidine, chitosan, allantoine and dexpanthenol versus a placebo for pain and inflammation control after third molar surgery.

Material and methods: A gel combining 0.2% chlorhexdine, 0.5% chitosan, 5% dexpanthenol, 0.15% allantoin and 0.01% sodium saccharin was selected for this split mouth randomized controlled and double-blind trial including 36 patients with bilaterally and symmetrically impacted lower third molars. The teeth (n=72) were randomly divided into two groups before surgical removal: control group (CG; in which a placebo was given) and experimental group (EG). Swelling, trismus, postoperative pain, wound healing and complications were measured and recorded in order to evaluate differences between the placebo and experimental product.

Results: Five patients suffered from an alveolitis in the CG (13.9%), and none in the study group (0%), but no statistically significant difference was found (p=0.063). From day 0 to day 7, trismus and swelling were significantly less pronounced in the EG, and wound healing was considered 'good' in 22.2% for the CG and 97.2% for the EG (p<0.001). Mean VAS scores during the seven postoperative days were statistically lower in the study (2.56±1,19) compared to the placebo group (3.25±1.6) (p=0.002). The mean consumption of analgesic pills during the first 92 hours was also statistically lower in the EG (0.26±0.51) in comparison to the CG (0.56±0.67) (p=0.003).

Conclusions: The use of an experimental gel containing chlorhexidine, chitosan, allantoine and dexpanthenol seems to significantly reduce postoperative pain, trismus and signs of inflammation. Future studies should further evaluate, if the gel is effective in dry socket preventing after third molar removal.

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Conflict of interest statement

Conflicts of interest The authors claim to have no financial interest, either directly or indirectly, in the products or information listed in the paper.

Figures

Figure 1
Figure 1
Flowchart diagram of the study protocol according to Consort guidelines.
Figure 2
Figure 2
Wound healing during the postoperative period.
Figure 3
Figure 3
VAS scores from day 0 to day 7 in each group.
See this image and copyright information in PMC

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