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. 2020 Jun 25:2020:2102158.
doi: 10.1155/2020/2102158. eCollection 2020.

Assessment of Serum Tumor Markers for Predicting Ocular Metastasis in Lung Adenocarcinoma: A Retrospective Study

Wen-Qing Shi  1 , Wen-Feng Liu  2 , Biao Li  1 , Qi Lin  1 , Qing-Hai Li  1 , Yu-Qing Zhang  1 , Qing Yuan  1 , Rong-Bin Liang  1 , Qian-Min Ge  1 , Yi Shao  1
Affiliations

Assessment of Serum Tumor Markers for Predicting Ocular Metastasis in Lung Adenocarcinoma: A Retrospective Study

Wen-Qing Shi et al. Dis Markers. .

Abstract

The purpose of this study was to detect clinical variations between lung adenocarcinoma patients with and without ocular metastasis (OM) to identify risk factors for OM and assess the diagnostic values. We included 1153 patients with lung adenocarcinoma in this study. Independent t-tests and chi-square tests were used to compare patients' clinical characteristics. Statistically significant parameters were analyzed by binary logistic regression to detect risk factors of OM. The results showed that the OM group had increased alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), cytokeratin fragment 19 (CYFRA 21-1), carbohydrate antigen- (CA-) 125, CA-153, and total prostate-specific antigen (TPSA) compared with the NOM group. CYFRA21-1 is the most useful biomarker for detecting OM in this population.

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Conflict of interest statement

This was not an industry-supported study. The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The clinical characteristics of patients with lung adenocarcinoma. OM: ocular metastasis; NOM: nonocular metastasis.
Figure 2
Figure 2
The ROC curves of risk factor for detecting OM in lung adenocarcinoma. ROC curves of CYFRA21-1, CA-123, and CA-153 as a single risk factor of OM. ROC: receiver operating characteristic; OM: ocular metastasis.
Figure 3
Figure 3
The ROC curves of combinations of different combinations of risk factors for detecting OM in lung adenocarcinoma patients and the ROC curves of CYFRA 21-1+CA-125, CYFRA 21-1+CA-153, CA-125+CA-153, and CYFRA 21-1+CA-125+CA-153. ROC: receiver operating characteristic; OM: ocular metastasis.
See this image and copyright information in PMC

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