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Comment
. 2020 Jul 20;5(1):126.
doi: 10.1038/s41392-020-00239-y.

Mitochondria hyperactivity contributes to social behavioral impairments

Yun Zhang #  1   2 , Lin Peng #  1   3 , Weihong Song  4   5   6
Affiliations
Comment

Mitochondria hyperactivity contributes to social behavioral impairments

Yun Zhang et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Mitochondrial hyperactivity reduces GABA neurotransmission, leading to social behavioral deficits. CYFIP haploinsuffiency enhances mitochondrial activity by increasing mitochondrion size, membrane potential, and energy metabolism, which further stimulates the mitochondrial translocation of GABA by Aralar carrier. The reduction of GABAergic signaling leads to the social behavioral deficits in neuropsychiatric disorders such as ASD, SCZ, and epilepsy
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References

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