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Comment
. 2020 Aug 3;219(8):e202007028.
doi: 10.1083/jcb.202007028.

ISG15 fast-tracks DNA replication

Alice Meroni  1 , Alessandro Vindigni  1
Affiliations
Comment

ISG15 fast-tracks DNA replication

Alice Meroni et al. J Cell Biol. .

Abstract

In this issue, Raso et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202002175) uncover a novel replication fork speed regulatory network controlled by the ubiquitin-like modifier interferon-stimulated gene 15 (ISG15), which plays a central role in the innate immune response and regulates tumorigenesis as well as chemotherapy response.

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Figures

Figure 1.
Figure 1.
The ISG15-RECQ1 network controls replication fork speed. High levels of ISG15 expression, which are triggered by the production of interferons and are commonly detected in many human tumors, stimulate the replication fork start activity of RECQ1, leading to accelerated fork speed and increased genomic instability.
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References

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