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Review
. 2020 Dec:65:151-159.
doi: 10.1016/j.gde.2020.05.042. Epub 2020 Jul 17.

Cortico-basal ganglia circuits underlying dysfunctional control of motor behaviors in neuropsychiatric disorders

Ana Mafalda Vicente  1 , Gabriela J Martins  1 , Rui M Costa  2
Affiliations
Review

Cortico-basal ganglia circuits underlying dysfunctional control of motor behaviors in neuropsychiatric disorders

Ana Mafalda Vicente et al. Curr Opin Genet Dev. 2020 Dec.

Abstract

Neuropsychiatric disorders often manifest with abnormal control of motor behavior. Common symptoms include restricted and repetitive patterns of behavior (RRBs). Cortico-basal ganglia circuits have been implicated in the etiology of RBBs. However, there is a vast range of behaviors encompassed in RRBs, from simple explosive motor tics to rather complex ritualized compulsions. In this review, we highlight how recent findings about the function of specific basal ganglia circuits can begin to shed light into defined motor symptoms associated with neuropsychiatric disorders. We discuss recent studies using genetic animal models that advocate that different aspects of motor repetition in neurodevelopmental disorders, like obsessive-compulsive disorder and autism spectrum disorder, emerge from particular dysregulations in distinct cortico-basal ganglia circuits.

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Conflict of interest statement

Conflict of Interest

No conflict of interest exists.

We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.

Figures

Figure 1:
Figure 1:
Diagram of cortico-basal ganglia circuitry
Figure 2:
Figure 2:
Model of basal ganglia circuitry in ASD with an imbalance favoring the direct versus the indirect pathway in dorsal striatum.
See this image and copyright information in PMC

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