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Review
. 2020 Jul 20;20(1):107.
doi: 10.1186/s12894-020-00676-5.

Squamous cell carcinoma of the renal parenchyma presenting as hydronephrosis: a case report and review of the recent literature

Xirong Zhang  1   2 , Yuanfeng Zhang  1 , Chengguo Ge  1 , Junyong Zhang  1 , Peihe Liang  3
Affiliations
Review

Squamous cell carcinoma of the renal parenchyma presenting as hydronephrosis: a case report and review of the recent literature

Xirong Zhang et al. BMC Urol. .

Abstract

Background: Primary squamous cell carcinoma of the renal parenchyma is extremely rare, only 5 cases were reported.

Case presentation: We probably report the fifth case of primary Squamous cell carcinoma (SCC) of the renal parenchyma in a 61-year-old female presenting with intermittent distending pain for 2 months. Contrast-enhanced computed tomography (CECT) revealed hydronephrosis of the right kidney, but a tumor cannot be excluded completely. Finally, nephrectomy was performed, and histological analysis determined that the diagnosis was kidney parenchyma squamous cell carcinoma involving perinephric adipose tissue.

Conclusions: The present case emphasizes that it is difficult to make an accurate preoperative diagnosis with the presentation of hidden malignancy, such as hydronephrosis.

Keywords: Hydronephrosis; Kidney; Malignancy; Renal parenchyma; Squamous cell carcinoma.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
a-c Contrast-enhanced computed tomography showed marked hydronephrosis of the right kidney and some perinephric exudates. d-f. Contrast-enhanced computed tomography revealed right gross hydronephrosis and right perinephric chronic inflammation; in the lower pole of the right kidney, a tumor could not be completely excluded with mild to moderate enhancement. g,h Plain scan of coronal and sagittal images
Fig. 2
Fig. 2
(upper) Histological examination, showing classical morphology of squamous carcinoma (HE staining, 200×). (Fig. 2 lower) immunohistochemistry, CK5/6 positive (200×)
Fig. 3
Fig. 3
immunohistochemistry of p63, positive (+++) (200×)
See this image and copyright information in PMC

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