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Randomized Controlled Trial
. 2020 Aug:38:129-137.
doi: 10.1016/j.clnesp.2020.05.016. Epub 2020 Jun 16.

Association of rs670 variant of APOA-1 gene with cardiometabolic markers after consuming sesame, canola and sesame-canola oils in adults with and without type 2 diabetes mellitus

Nahid Ramezani-Jolfaie  1 , Shiva Aghaei  2 , Ehsan Farashahi Yazd  2 , Ali Moradi  3 , Hassan Mozaffari-Khosravi  4 , Alireza Zimorovat  1 , Hamidreza Raeisi-Dehkordi  1 , Fatemeh Moghtaderi  1 , Mojgan Amiri  1 , Seyed Ali Yasini Ardakani  5 , Amin Salehi-Abargouei  6
Affiliations
Randomized Controlled Trial

Association of rs670 variant of APOA-1 gene with cardiometabolic markers after consuming sesame, canola and sesame-canola oils in adults with and without type 2 diabetes mellitus

Nahid Ramezani-Jolfaie et al. Clin Nutr ESPEN. 2020 Aug.

Abstract

Background & aims: The inter-individual variations of the metabolic markers in response to dietary interventions may be mediated by genetic factors. We examined whether the type of dietary oils can modulate the effects of -75G/A polymorphism in APOA-1 gene on cardiometabolic markers.

Methods: This study was a randomized, triple-blind, cross-over clinical trial. Participants with and without type 2 diabetes were randomly assigned to replace their regular oil with sesame oil, canola oil and sesame-canola oil for 9 weeks. Genotyping was conducted using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

Results: Ninety-five diabetes patients and 73 healthy individuals completed the study protocol. In patients with type 2 diabetes, the A allele carriers experienced greater decrease in systolic blood pressure compared with GG homozygotes following sesame-canola oil intake. Serum levels of HDL-C and TG: HDL ratio was increased and decreased following canola oil intake in patients carrying the A allele rather than non-A allele carriers, respectively. More reductions for risk of cardiovascular diseases and mortality, except risk of stroke were found in the A allele carriers compared with GG homozygotes after intakes of canola and sesame-canola oils, but not sesame oil. There was also a significant genotype effect as well as genotype-dietary oil interactions on cardiovascular risk scores. In healthy individuals, a considerable decrease in visceral fat was accompanied by a significant increase in HDL-C levels in the A allele carriers compared with non-A allele carriers after sesame oil intake.

Conclusion: Patients with diabetes carrying the A allele might benefit from canola and sesame-canola oils intakes, and healthy A allele carriers from sesame and sesame-canola oils intakes as well. Future clinical trials are recommended to warrant current findings.

Keywords: Apolipoprotein A-I; Cardiovascular risk factors; Genetic polymorphism; Rapeseed oil; Sesame oil; Type 2 diabetes mellitus.

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Conflict of interest statement

Declaration of Competing Interest The study was jointly funded by Shahid Sadoughi University of Medical Sciences (http://www.ssu.ac.ir) and Datis Corporation (http://www.neshatavar.com/?l=EN). Datis Corporation provided all of the intervention dietary oils consumed during the study. The investigators state that they did not have a direct financial relationship with Datis Corporation. Shahid Sadoughi University of Medical Sciences received the funds and delivered it to the investigators. Datis Corporation had no role in design and conduction of the study, data collection, data management, analysis and interpretation of the data, and also preparation of this manuscript. Datis Corporation did not have any other relationship with the investigators. The authors declare that they have no other potential personal or financial conflicts of interest. The principal investigator (ASA) declares that he has full access to the data provided by this project.

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