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. 2020 Jul 20;10(7):e037473.
doi: 10.1136/bmjopen-2020-037473.

Systematic review of the global epidemiology of viral-induced acute liver failure

Jenna Patterson  1 , Hannah Sophia Hussey  2 , Sheetal Silal  3   4 , Liz Goddard  5 , Mashiko Setshedi  6 , Wendy Spearman  7 , Gregory D Hussey  2   8 , Benjamin M Kagina  2 , Rudzani Muloiwa  2   9
Affiliations

Systematic review of the global epidemiology of viral-induced acute liver failure

Jenna Patterson et al. BMJ Open. .

Abstract

Objectives: The aetiology and burden of viral-induced acute liver failure remains unclear globally. It is important to understand the epidemiology of viral-induced ALF to plan for clinical case management and case prevention.

Participants: This systematic review was conducted to synthesize data on the relative contribution of different viruses to the aetiology of viral-induced acute liver failure in an attempt to compile evidence that is currently missing in the field. EBSCOhost, PubMed, ScienceDirect, Scopus and Web of Science were searched for relevant literature published from 2009 to 2019. The initial search was run on 9 April 2019 and updated via PubMed on 30 September 2019 with no new eligible studies to include. Twenty-five eligible studies were included in the results of this review.

Results: This systematic review estimated the burden of acute liver failure after infection with hepatitis B virus, hepatitis A virus, hepatitis C virus, hepatitis E virus, herpes simplex virus/human herpesvirus, cytomegalovirus, Epstein-Barr virus and parvovirus B19. Data were largely missing for acute liver failure after infection with varicella-zostervirus, human parainfluenza viruses, yellow fever virus, coxsackievirus and/or adenovirus. The prevalence of hepatitis A-induced acute liver failur was markedly lower in countries with routine hepatitis A immunisation versus no routine hepatitis A immunisation. Hepatitis E virus was the most common aetiological cause of viral-induced acute liver failure reported in this review. In addition, viral-induced acute liver failure had poor outcomes as indicated by high fatality rates, which appear to increase with poor economic status of the studied countries.

Conclusions: Immunisation against hepatitis A and hepatitis B should be prioritised in low-income and middle-income countries to prevent high viral-induced acute liver failure mortality rates, especially in settings where resources for managing acute liver failure are lacking. The expanded use of hepatitis E immunisation should be explored as hepatitis E virus was the most common cause of acute liver failure.

Registration: PROSPERO registration number: CRD42017079730.

Keywords: epidemiology; hepatology; virology.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Flow diagram for selection of studies.
Figure 2
Figure 2
Prevalence of HAV-induced ALF by country HAV immunisation status. ALF, acute liver failure; HAV, hepatitis A virus; I2, heterogeneity statistic.
Figure 3
Figure 3
Prevalence of HBV-induced ALF by country HBV immunisation status. ALF, acute liver failure; HBV=hepatitis B virus; I2, heterogeneity statistic.
Figure 4
Figure 4
Prevalence of outcomes associated with viral-induced ALF. ALF, acute liver failure; I2, heterogeneity statistic; NA, not applicable.
See this image and copyright information in PMC

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