Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Mev Dominguez-Valentin^#¹, Julian R Sampson^#², Toni T Seppälä^#^{3

4}, Sanne W Ten Broeke⁵, John-Paul Plazzer⁶, Sigve Nakken⁷, Christoph Engel⁸, Stefan Aretz⁹, Mark A Jenkins¹⁰, Lone Sunde^{11

12}, Inge Bernstein¹³, Gabriel Capella¹⁴, Francesc Balaguer¹⁵, Huw Thomas¹⁶, D Gareth Evans^{17

18}, John Burn¹⁹, Marc Greenblatt²⁰, Eivind Hovig^{7

21}, Wouter H de Vos Tot Nederveen Cappel²², Rolf H Sijmons²³, Lucio Bertario²⁴, Maria Grazia Tibiletti²⁵, Giulia Martina Cavestro²⁶, Annika Lindblom²⁷, Adriana Della Valle²⁸, Francisco Lopez-Köstner²⁹, Nathan Gluck³⁰, Lior H Katz³¹, Karl Heinimann³², Carlos A Vaccaro^{33

34}, Reinhard Büttner³⁵, Heike Görgens³⁶, Elke Holinski-Feder^{37

38}, Monika Morak^{37

38}, Stefanie Holzapfel⁹, Robert Hüneburg³⁹, Magnus von Knebel Doeberitz^{40

41}, Markus Loeffler⁸, Nils Rahner⁴², Hans K Schackert³⁶, Verena Steinke-Lange^{37

38}, Wolff Schmiegel⁴³, Deepak Vangala⁴³, Kirsi Pylvänäinen⁴⁴, Laura Renkonen-Sinisalo^{45

46}, John L Hopper¹⁰, Aung Ko Win¹⁰, Robert W Haile⁴⁷, Noralane M Lindor⁴⁸, Steven Gallinger⁴⁹, Loïc Le Marchand⁵⁰, Polly A Newcomb⁵¹, Jane C Figueiredo⁵², Stephen N Thibodeau⁵³, Karin Wadt⁵⁴, Christina Therkildsen⁵⁵, Henrik Okkels⁵⁶, Zohreh Ketabi⁵⁷, Leticia Moreira¹⁵, Ariadna Sánchez¹⁵, Miquel Serra-Burriel⁵⁸, Marta Pineda⁵⁹, Matilde Navarro⁵⁹, Ignacio Blanco⁵⁹, Kate Green¹⁷, Fiona Lalloo¹⁷, Emma J Crosbie⁶⁰, James Hill⁶¹, Oliver G Denton⁶², Ian M Frayling⁶², Einar Andreas Rødland⁷, Hans Vasen⁶³, Miriam Mints⁶⁴, Florencia Neffa²⁸, Patricia Esperon²⁸, Karin Alvarez²⁹, Revital Kariv³⁰, Guy Rosner³⁰, Tamara Alejandra Pinero^{33

34}, María Laura Gonzalez³³, Pablo Kalfayan³³, Douglas Tjandra⁶⁵, Ingrid M Winship^{65

66}, Finlay Macrae^{6

65}, Gabriela Möslein⁶⁷, Jukka-Pekka Mecklin⁶⁸, Maartje Nielsen⁵, Pål Møller^{7

69

70}

Affiliations

¹ Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. mev.dominguez.valentin@rr-research.no.
² Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK. sampson@cardiff.ac.uk.
³ Department of Gastrointestinal Surgery, Helsinki University Central Hospital, Helsinki, Finland. toni.seppala@fimnet.fi.
⁴ Clinicum, University of Helsinki, Helsinki, Finland. toni.seppala@fimnet.fi.
⁵ Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
⁶ Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Australia.
⁷ Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
⁸ Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
⁹ Institute of Human Genetics, University of Bonn, Bonn, Germany.
¹⁰ Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.
¹¹ Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
¹² Department of Biomedicine, Aarhus University, Aarhus, Denmark.
¹³ Department of Surgical Gastroenterology, Aalborg University Hospital, Aalborg, Denmark.
¹⁴ Hereditary Cancer Program, Institut Catal. d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
¹⁵ Gastroenterology Department, Hospital Clinic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain.
¹⁶ St Mark's Hospital, Department of Surgery and Cancer, Imperial College London, London, UK.
¹⁷ Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
¹⁸ Manchester Centre for Genomic Medicine, University of Manchester, Manchester, UK.
¹⁹ Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
²⁰ University of Vermont College of Medicine, Burlington, VT, USA.
²¹ Institute of Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
²² Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands.
²³ Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.
²⁴ Unit of Hereditary Digestive Tract Tumors IRCCS Istituto Nazionale Tumori and Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy.
²⁵ Ospedale di Circolo ASST Settelaghi, Centro di Ricerca tumori eredo-familiari, Università dell'Insubria, Varese, Italy.
²⁶ Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy.
²⁷ Department of Molecular Medicine and Surgery and Department of Clinical Genetics, Karolinska Institutet and University Hospital, Stockholm, Sweden.
²⁸ Hospital Fuerzas Armadas, Grupo Colaborativo Uruguayo, Investigación de Afecciones Oncológicas Hereditarias (GCU), Montevideo, Uruguay.
²⁹ Lab. Oncología y Genética Molecular, Unidad de coloproctología, Clínica Las Condes, Santiago, Chile.
³⁰ Department of Gastroenterology, Tel Aviv Sourasky Medical Centre and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
³¹ High Risk and GI Cancer prevention Clinic, Gastro-Oncology Unit, The Department of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel.
³² Institute for Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
³³ Hereditary Cancer Program (PROCANHE), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
³⁴ Instituto de Medicina Traslacional e Ingenieria Biomedica (IMTIB), CONICET IU, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
³⁵ Institute of Pathology, University of Cologne, Cologne, Germany.
³⁶ Department of Surgical Research, Technische Universität Dresden, Dresden, Germany.
³⁷ Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany.
³⁸ Center of Medical Genetics, Munich, Germany.
³⁹ Department of Internal Medicine, University Hospital Bonn, Bonn, Germany.
⁴⁰ Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
⁴¹ Cooperation Unit Applied Tumour Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁴² Institute of Human Genetics, Medical School, Heinrich-Heine-University, Dusseldorf, Germany.
⁴³ Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany.
⁴⁴ Department of Education and Science, Central Finland Health Care District, Jyväskylä, Finland.
⁴⁵ Department of Gastrointestinal Surgery, Helsinki University Central Hospital, Helsinki, Finland.
⁴⁶ Applied Tumour Genomics Research Program, University of Helsinki, Helsinki, Finland.
⁴⁷ Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University, Palo Alto, CA, USA.
⁴⁸ Department of Health Science Research, Mayo Clinic Arizona, Phoenix, AZ, USA.
⁴⁹ Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
⁵⁰ University of Hawaii Cancer Center, Honolulu, HI, USA.
⁵¹ Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
⁵² Cedars-Sinai Medical Center, Los Angeles, CA, USA.
⁵³ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
⁵⁴ Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark.
⁵⁵ The Danish HNPCC Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.
⁵⁶ Department of Molecular Diagnostics, Aalborg University Hospital, Aalborg, Denmark.
⁵⁷ Department of Obstetrics and Gynaecology, Copenhagen University Hospital, Rigshospitalet, Denmark.
⁵⁸ Universitat de Barcelona & Centre de Recerca en Economia i Salut (CRES-UPF), Barcelona, Spain.
⁵⁹ Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
⁶⁰ Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester and St Mary's Hospital, Manchester, UK.
⁶¹ Department of Surgery, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester, Manchester, UK.
⁶² Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK.
⁶³ Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands.
⁶⁴ Department of Women's and Children's health, Division of Obstetrics and Gyneacology, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden.
⁶⁵ Department of Medicine, Melbourne University, Melbourne, Australia.
⁶⁶ Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Australia.
⁶⁷ Surgical Center for Hereditary Tumors, HELIOS University Clinic Wuppertal, University of Witten-Hardecke, Wuppertal, Germany.
⁶⁸ Departments of Surgery, University of Jyväskylä and Central Finland Central Hospital, Jyväskylä, Finland.
⁶⁹ Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
⁷⁰ Centre for Cancer Cell Reprogamming, University of Oslo, Oslo, Norway.

^# Contributed equally.

PMID: 32690931
PMCID: PMC7462742
DOI: 10.1038/s41436-020-0892-4

Published Erratum

Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Mev Dominguez-Valentin et al. Genet Med. 2020 Sep.

. 2020 Sep;22(9):1569.

doi: 10.1038/s41436-020-0892-4.

Authors

Affiliations

¹ Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. mev.dominguez.valentin@rr-research.no.
² Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK. sampson@cardiff.ac.uk.
³ Department of Gastrointestinal Surgery, Helsinki University Central Hospital, Helsinki, Finland. toni.seppala@fimnet.fi.
⁴ Clinicum, University of Helsinki, Helsinki, Finland. toni.seppala@fimnet.fi.
⁵ Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
⁶ Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Australia.
⁷ Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
⁸ Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
⁹ Institute of Human Genetics, University of Bonn, Bonn, Germany.
¹⁰ Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.
¹¹ Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
¹² Department of Biomedicine, Aarhus University, Aarhus, Denmark.
¹³ Department of Surgical Gastroenterology, Aalborg University Hospital, Aalborg, Denmark.
¹⁴ Hereditary Cancer Program, Institut Catal. d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
¹⁵ Gastroenterology Department, Hospital Clinic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain.
¹⁶ St Mark's Hospital, Department of Surgery and Cancer, Imperial College London, London, UK.
¹⁷ Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
¹⁸ Manchester Centre for Genomic Medicine, University of Manchester, Manchester, UK.
¹⁹ Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
²⁰ University of Vermont College of Medicine, Burlington, VT, USA.
²¹ Institute of Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
²² Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands.
²³ Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.
²⁴ Unit of Hereditary Digestive Tract Tumors IRCCS Istituto Nazionale Tumori and Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy.
²⁵ Ospedale di Circolo ASST Settelaghi, Centro di Ricerca tumori eredo-familiari, Università dell'Insubria, Varese, Italy.
²⁶ Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy.
²⁷ Department of Molecular Medicine and Surgery and Department of Clinical Genetics, Karolinska Institutet and University Hospital, Stockholm, Sweden.
²⁸ Hospital Fuerzas Armadas, Grupo Colaborativo Uruguayo, Investigación de Afecciones Oncológicas Hereditarias (GCU), Montevideo, Uruguay.
²⁹ Lab. Oncología y Genética Molecular, Unidad de coloproctología, Clínica Las Condes, Santiago, Chile.
³⁰ Department of Gastroenterology, Tel Aviv Sourasky Medical Centre and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
³¹ High Risk and GI Cancer prevention Clinic, Gastro-Oncology Unit, The Department of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel.
³² Institute for Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
³³ Hereditary Cancer Program (PROCANHE), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
³⁴ Instituto de Medicina Traslacional e Ingenieria Biomedica (IMTIB), CONICET IU, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
³⁵ Institute of Pathology, University of Cologne, Cologne, Germany.
³⁶ Department of Surgical Research, Technische Universität Dresden, Dresden, Germany.
³⁷ Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany.
³⁸ Center of Medical Genetics, Munich, Germany.
³⁹ Department of Internal Medicine, University Hospital Bonn, Bonn, Germany.
⁴⁰ Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
⁴¹ Cooperation Unit Applied Tumour Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁴² Institute of Human Genetics, Medical School, Heinrich-Heine-University, Dusseldorf, Germany.
⁴³ Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany.
⁴⁴ Department of Education and Science, Central Finland Health Care District, Jyväskylä, Finland.
⁴⁵ Department of Gastrointestinal Surgery, Helsinki University Central Hospital, Helsinki, Finland.
⁴⁶ Applied Tumour Genomics Research Program, University of Helsinki, Helsinki, Finland.
⁴⁷ Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University, Palo Alto, CA, USA.
⁴⁸ Department of Health Science Research, Mayo Clinic Arizona, Phoenix, AZ, USA.
⁴⁹ Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
⁵⁰ University of Hawaii Cancer Center, Honolulu, HI, USA.
⁵¹ Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
⁵² Cedars-Sinai Medical Center, Los Angeles, CA, USA.
⁵³ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
⁵⁴ Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark.
⁵⁵ The Danish HNPCC Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.
⁵⁶ Department of Molecular Diagnostics, Aalborg University Hospital, Aalborg, Denmark.
⁵⁷ Department of Obstetrics and Gynaecology, Copenhagen University Hospital, Rigshospitalet, Denmark.
⁵⁸ Universitat de Barcelona & Centre de Recerca en Economia i Salut (CRES-UPF), Barcelona, Spain.
⁵⁹ Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
⁶⁰ Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester and St Mary's Hospital, Manchester, UK.
⁶¹ Department of Surgery, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester, Manchester, UK.
⁶² Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK.
⁶³ Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands.
⁶⁴ Department of Women's and Children's health, Division of Obstetrics and Gyneacology, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden.
⁶⁵ Department of Medicine, Melbourne University, Melbourne, Australia.
⁶⁶ Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Australia.
⁶⁷ Surgical Center for Hereditary Tumors, HELIOS University Clinic Wuppertal, University of Witten-Hardecke, Wuppertal, Germany.
⁶⁸ Departments of Surgery, University of Jyväskylä and Central Finland Central Hospital, Jyväskylä, Finland.
⁶⁹ Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
⁷⁰ Centre for Cancer Cell Reprogamming, University of Oslo, Oslo, Norway.

^# Contributed equally.

PMID: 32690931
PMCID: PMC7462742
DOI: 10.1038/s41436-020-0892-4

Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

PubMed Disclaimer

Erratum for

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.
Dominguez-Valentin M, Sampson JR, Seppälä TT, Ten Broeke SW, Plazzer JP, Nakken S, Engel C, Aretz S, Jenkins MA, Sunde L, Bernstein I, Capella G, Balaguer F, Thomas H, Evans DG, Burn J, Greenblatt M, Hovig E, de Vos Tot Nederveen Cappel WH, Sijmons RH, Bertario L, Tibiletti MG, Cavestro GM, Lindblom A, Della Valle A, Lopez-Köstner F, Gluck N, Katz LH, Heinimann K, Vaccaro CA, Büttner R, Görgens H, Holinski-Feder E, Morak M, Holzapfel S, Hüneburg R, Knebel Doeberitz MV, Loeffler M, Rahner N, Schackert HK, Steinke-Lange V, Schmiegel W, Vangala D, Pylvänäinen K, Renkonen-Sinisalo L, Hopper JL, Win AK, Haile RW, Lindor NM, Gallinger S, Le Marchand L, Newcomb PA, Figueiredo JC, Thibodeau SN, Wadt K, Therkildsen C, Okkels H, Ketabi Z, Moreira L, Sánchez A, Serra-Burriel M, Pineda M, Navarro M, Blanco I, Green K, Lalloo F, Crosbie EJ, Hill J, Denton OG, Frayling IM, Rødland EA, Vasen H, Mints M, Neffa F, Esperon P, Alvarez K, Kariv R, Rosner G, Pinero TA, Gonzalez ML, Kalfayan P, Tjandra D, Winship IM, Macrae F, Möslein G, Mecklin JP, Nielsen M, Møller P. Dominguez-Valentin M, et al. Genet Med. 2020 Jan;22(1):15-25. doi: 10.1038/s41436-019-0596-9. Epub 2019 Jul 24. Genet Med. 2020. PMID: 31337882 Free PMC article.

Publication types

Actions

LinkOut - more resources

Full Text Sources

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Affiliations

Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Authors

Affiliations

Abstract

Erratum for

Publication types

LinkOut - more resources

Full Text Sources