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Comment
. 2020 Sep 1;41(33):3198-3199.
doi: 10.1093/eurheartj/ehaa534.

Reduction in ACE2 may mediate the prothrombotic phenotype in COVID-19

Ying X Gue  1 , Diana A Gorog  1   2
Affiliations
Comment

Reduction in ACE2 may mediate the prothrombotic phenotype in COVID-19

Ying X Gue et al. Eur Heart J. .
No abstract available

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Figures

Take home figure
Take home figure
Thrombotic complications in patients with COVID-19 related to angiotensin-converting enzyme 2 (ACE2) activity. SARS-CoV-2 binding to ACE2 receptors induces enhanced shredding of ACE2, with a resultant (1) increase vascular permeability, subsequent tissue factor exposure, and activation of extrinsic coagulation pathway; and (2) increase in angiotensin II levels, subsequent increase in plasminogen activator inhibitor 1 (PAI-1) levels, and reduction of fibrinolytic activity.
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