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Review
. 2020 Jul 20;22(9):47.
doi: 10.1007/s11926-020-00924-5.

Treatment of Axial Spondyloarthritis: What Does the Future Hold?

Denis Poddubnyy  1   2 , Joachim Sieper  3
Affiliations
Review

Treatment of Axial Spondyloarthritis: What Does the Future Hold?

Denis Poddubnyy et al. Curr Rheumatol Rep. .

Abstract

Purpose of review: To provide a summary of the recent and expected developments related to the treatment of axial spondyloarthritis.

Recent findings: An increasing number of interleukin-17 blocking agents show efficacy in axial spondyloarthritis including both non-radiographic and radiographic forms. Janus kinase inhibitors showed promising results in phase II studies in radiographic axial spondyloarthritis and have, therefore, a potential to become a therapeutic option in this indication in the future. Inhibition of structural damage progression in axial spondyloarthritis seems to be possible in the case of effective and early anti-inflammatory treatment, although there are still open questions related to particular drug classes. Despite major advances in the field and growing therapeutic options, there are still many open questions related to the optimized treatment strategies and to the individual choice of a drug in axial spondyloarthritis.

Keywords: Ankylosing spondylitis; Axial spondyloarthritis; Treatment.

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Conflict of interest statement

Denis Poddubnyy has received grant/research support from AbbVie, Lilly, MSD, Novartis, and Pfizer; has received consultation and/or speaker fees from AbbVie, Biocad, BMS, Gilead, GSK, Lilly, MSD, Novartis, Pfizer, Samsung and UCB.

Joachim Sieper has received consultation and/or speaker fees from AbbVie, Boehringer Ingelheim, Janssen, Merk, Novartis, Pfizer, Roche, and UCB.

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