Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb;71(2):394-408.
doi: 10.1007/s12031-020-01662-0. Epub 2020 Jul 20.

CDH13 and LPHN3 Gene Polymorphisms in Attention-Deficit/Hyperactivity Disorder: Their Relation to Clinical Characteristics

Ahmet Özaslan  1 , Esra Güney  2 , Mehmet Ali Ergün  3 , İlyas Okur  4 , Dilek Yapar  5
Affiliations

CDH13 and LPHN3 Gene Polymorphisms in Attention-Deficit/Hyperactivity Disorder: Their Relation to Clinical Characteristics

Ahmet Özaslan et al. J Mol Neurosci. 2021 Feb.

Abstract

Genetic factors play a major role in the etiopathogenesis of attention-deficit/hyperactivity disorder (ADHD). In this study, we aimed to investigate the relationship between the CDH13 (rs6565113, rs11150556) and LPHN3 (rs6551665, rs6858066, rs1947274, rs2345039) gene polymorphisms and ADHD. We also sought to examine possible relationships between these polymorphisms and the clinical course and treatment response in ADHD. A total of 120 patients (79% boys), aged 6 to 18 years, newly diagnosed (medication-naïve) with ADHD according to the DSM-5 and a group of 126 controls (74% girls) were enrolled in the study. We examined the association between the aforementioned polymorphisms and ADHD. Univariate and multivariate logistic regression analysis were used to evaluate factors influencing the treatment response of ADHD. A significant difference was found between ADHD and control groups in terms of genotype distribution of the LPHN3 rs6551665 and rs1947274 polymorphisms. The results also showed that having the GG genotype of rs6551665 and CC genotype of rs1947274 of the LPHN3 gene was associated with risk for ADHD, and this relationship was more prominent in male participants. In the multivariate logistic regression model established with variables shown to have a significant relationship with treatment response, the presence of the GG genotype of the LPHN3 rs6551665 polymorphism and high severity of ADHD assessed by CGI-S were associated with poor response to treatment. This study is the first study to investigate the relationship between ADHD and these polymorphisms among Turkish adolescents. Our results imply that the LPHN3 rs6551665 and rs1947274 polymorphisms have a significant effect on ADHD in a Turkish population, and support previous observations that the presence of the GG genotype of the LPHN3 rs6551665 polymorphism may be associated with poor response to treatment in ADHD.

Keywords: Attention-deficit/hyperactivity disorder; CDH13; LPHN3; Response to treatment.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Acosta MT et al (2016) ADGRL3 (LPHN3) variants are associated with a refined phenotype of ADHD in the MTA study. Mol Genet Genomic Med 4:540–547. https://doi.org/10.1002/mgg3.230 - DOI - PubMed - PMC
    1. Adamo N, Seth S, Coghill D (2015) Pharmacological treatment of attention-deficit/hyperactivity disorder: assessing outcomes. Expert Rev Clin Pharmacol 8(4):383–397. https://doi.org/10.1586/17512433.2015.1050379 - DOI - PubMed
    1. American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub, Arlington. https://doi.org/10.1176/appi.books.9780890425596 - DOI
    1. Arcos-Burgos M et al (2004) Attention-deficit/hyperactivity disorder in a population isolate: linkage to loci at 4q13. 2, 5q33. 3, 11q22, and 17p11. Am J Hum Genet 75(6):998–1014. https://doi.org/10.1086/426154 - DOI - PubMed - PMC
    1. Arcos-Burgos Á et al (2010) A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Mol Psychiatry 15(11):1053–1066. https://doi.org/10.1038/mp.2010.6 - DOI - PubMed

LinkOut - more resources