Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Feb;93(2):726-732.
doi: 10.1002/jmv.26321. Epub 2020 Jul 28.

HIV/SARS-CoV-2 coinfection: A global perspective

Osman N Kanwugu  1 , Parise Adadi  2
Affiliations
Review

HIV/SARS-CoV-2 coinfection: A global perspective

Osman N Kanwugu et al. J Med Virol. 2021 Feb.

Abstract

Since its first appearance in Wuhan, China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread throughout the world and has become a global pandemic. Several medical comorbidities have been identified as risk factors for coronavirus disease 2019 (COVID-19). However, it remains unclear whether people living with human immunodefeciency virus (PLWH) are at an increased risk of COVID-19 and severe disease manifestation, with controversial suggestion that HIV-infected individuals could be protected from severe COVID-19 by means of antiretroviral therapy or HIV-related immunosuppression. Several cases of coinfection with HIV and SARS-CoV-2 have been reported from different parts of the globe. This review seeks to provide a holistic overview of SARS-CoV-2 infection in PLWH.

Keywords: COVID-19; HIV; antiretroviral therapy/coinfection; immunodeficiency.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Demographic characteristics of HIV/SARS‐CoV‐2 coinfected patients
Figure 2
Figure 2
Disease Severity associated with HIV/SARS‐CoV‐2 coinfected patients
Figure 3
Figure 3
Outcome reported endpoint for HIV/SARS‐CoV‐2 coinfected patients
Figure 4
Figure 4
Common comorbidities associated with HIV/SARS‐CoV‐2 coinfection. CVD, cardiovascular diseases; HLD, hyperlipidemia
See this image and copyright information in PMC

References

    1. World Health Organization . Coronavirus disease 2019 (COVID‐19): situation reports. 2020.
    1. University JH . Johns Hopkins Coronavirus Resource Center. 2020. https://coronavirus.jhu.edu/map.html2020)
    1. Sun Y, Koh V, Marimuthu K, et al. Epidemiological and clinical predictors of COVID‐19. Clin Infect Dis. 2020. 10.1093/cid/ciaa322 - DOI - PMC - PubMed
    1. World Health Organization . Clinical management of severe acute respiratory infection (SARI) when COVID‐19 disease is suspected: interim guidance, 13 March 2020: World Health Organization, 2020.
    1. Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID‐19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;46(5):846‐848. - PMC - PubMed

MeSH terms

Substances