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Meta-Analysis
. 2020 Jul 21;10(1):12102.
doi: 10.1038/s41598-020-69078-9.

Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis

Jean Joel Bigna  1 , Joel Noutakdie Tochie  2 , Dahlia Noelle Tounouga  2 , Anne Olive Bekolo  2 , Nadia S Ymele  3 , Emilie Lettitia Youda  3   4 , Paule Sandra Sime  2 , Jobert Richie Nansseu  2   5
Affiliations
Meta-Analysis

Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis

Jean Joel Bigna et al. Sci Rep. .

Abstract

Efficient health-care for pregnant women require accurate data on the prevalence of toxoplasmosis in pregnancy at global, regional, and country levels. In this systematic review with meta- and modelling-analysis, we searched PubMed, EMBASE, Web of Knowledge, Global Index Medicus, and Africa Journal Online to identify studies that reported enough data to compute the immunoglobulins (Ig) M or G seroprevalence estimates of Toxoplasma gondii in pregnant women up to December 31st, 2018, without any language restriction. The global and regional estimates were done using a random-effects meta-analysis. We included 250 studies with 723,655 pregnant women. The global IgM seroprevalence was 1.9% (95%CI: 1.7-2.3). At the regional level, Eastern Mediterranean had the highest IgM seroprevalence (4.1%, 95%CI: 2.8-5.5) and The Americas, the lowest (1.1%, 0.8-1.4), with a statistically significant difference between WHO regions (p < 0.0001). The global IgG seroprevalence was 32.9% (95%CI: 29.4-36.4). Among WHO regions, The Americas had the highest prevalence (45.2%, 95%CI: 33.4-53.4) and Western Pacific the lowest (11.2%, 7.8-15.1), with a statistically significant difference between regions (p < 0.0001). This study presents a high toxoplasma seropositivity in pregnant women at global, regional and country levels, with a consequential high risk of maternal and congenital toxoplasmosis.

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Conflict of interest statement

The authors declare no competing interest.

Figures

Figure 1
Figure 1
Global distribution of Toxoplasma gondii immunoglobulins M seroprevalence in pregnant women.
Figure 2
Figure 2
Meta-analysis prevalence of Toxoplasma gondii immunoglobulins M seroprevalence in pregnant women by WHO regions.
Figure 3
Figure 3
Meta-analysis prevalence of Toxoplasma gondii immunoglobulins M seroprevalence in pregnant women by country level of income.
Figure 4
Figure 4
Global distribution of Toxoplasma gondii immunoglobulins G seroprevalence in pregnant women.
Figure 5
Figure 5
Meta-analysis prevalence of Toxoplasma gondii immunoglobulins G seroprevalence in pregnant women by WHO regions.
Figure 6
Figure 6
Meta-analysis prevalence of Toxoplasma gondii immunoglobulins G seroprevalence in pregnant women by country level of income.
See this image and copyright information in PMC

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