Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun 12;13(3):477-479.
doi: 10.1093/ckj/sfaa095. eCollection 2020 Jun.

Targeting complement in severe coronavirus disease 2019 to address microthrombosis

Francisco Valga  1 , Nicanor Vega-Díaz  1 , Manuel Macia  2 , Tania Monzón  3 , Jose C Rodriguez-Perez  1
Affiliations

Targeting complement in severe coronavirus disease 2019 to address microthrombosis

Francisco Valga et al. Clin Kidney J. .
No abstract available

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Proposed pathogenesis for COVID-19, adapted from Chang [2], which includes endothelial dysfunction as the origin of the damage and the two main pathways. The first is the inflammatory pathway that would be related to the activation of monocytes–macrophages triggering the ‘cytokine storm’ leading to a systemic inflammatory response syndrome that usually occurs in association with ARDS and, ultimately, multi-organ failure. The second is the microthrombotic , closely related to activation of the complement, platelet and coagulation disorders. Also, there are factors that interact with both pathways, for example, the inducible serine protease that activates C5; some cytokines favour the development of disseminated intravascular coagulation and hypoxia favours a prothrombotic state per se by stimulating thrombin.
See this image and copyright information in PMC

References

    1. Siddiqi HK, Mehra MR.. COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal. J Heart Lung Transplant 2020; doi:10.1016/j.healun.2020.03.012 - PMC - PubMed
    1. Chang JC. Acute respiratory distress syndrome as an organ phenotype of vascular microthrombotic disease: based on hemostatic theory and endothelial molecular pathogenesis. Clin Appl Thromb Hemost 2019; 25: 107602961988743 - PMC - PubMed
    1. Xu Z, Shi L, Wang Y. et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 2020; 8: 420–422 - PMC - PubMed
    1. Tian S, Hu W, Niu L. et al. Pulmonary pathology of early-phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer. J Thorac Oncol 2020; doi:10.1016/j.jtho.2020.02.010 - PMC - PubMed
    1. Su H, Yang M, Wan C. et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int 2020; doi:10.1016/j.kint.2020.04.003 - PMC - PubMed