Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Apr 13;8(7):1130-1133.
doi: 10.1002/ccr3.2837. eCollection 2020 Jul.

Gastric EBV-positive mucocutaneous ulcer: A rare pathological entity

Azza Gabsi  1 , Yosr Zenzri  1 , Ghada Sahraoui  2 , Ihsen Ben Brahim  3 , Mouna Cherif  4 , Yosra Yahyaoui  1 , Nesrine Chraiet  1 , Karima Mrad  2 , Achraf Chedly  3 , Anis Ben Maamer  4 , Amel Mezlini  1
Affiliations
Case Reports

Gastric EBV-positive mucocutaneous ulcer: A rare pathological entity

Azza Gabsi et al. Clin Case Rep. .

Abstract

The gastric location of EBVMCU is extremely rare. The pathology examination and immunochemistry are mandatory for the diagnosis. It is essential that physicians be aware of this new entity to accurately diagnose and handle this disease.

Keywords: Epstein‐Barr virus; gastrointestinal; mucocutaneous; ulcer.

PubMed Disclaimer

Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
A subcardial ulcerous budding lesion in the greater stomach tuberosity
Figure 2
Figure 2
Large ulcerous lesion in the lesser curvature
Figure 3
Figure 3
Multiple ulcers were observed in the gastric body and the fundus
Figure 4
Figure 4
Extensive ulceration with fibrin and leukocyte exudates in the gastric mucosa
Figure 5
Figure 5
Atypical cells with basophilic cytoplasm resembling Hodgkin Reed‐Sternberg cells associated with lymphocytes, histiocytes, plasma cells, and neutrophils (G ×40)
Figure 6
Figure 6
Heterogeneous expression of CD15
Figure 7
Figure 7
Cells positive to EBV
Figure 8
Figure 8
Heterogeneous expression of CD20
Figure 9
Figure 9
CD3 marks reactive T lymphocytes
See this image and copyright information in PMC

References

    1. Dojcinov SD, Venkataraman G, Raffeld M, Pittaluga S, Jaffe ES. EBV positive mucocutaneous ulcer‐a study of 26 cases associated with various sources of immunosuppression. Am J Surg Pathol. 2010;34:405‐417. - PMC - PubMed
    1. Wanderlei KC, Quintella DC, Cuzzi T, et al. EBV‐positive mucocutaneous ulcers: a presentation of two cases and a brief literature review. Surg Exp Pathol. 2019;2:13.
    1. Oyama T, Ichimura K, Suzuki R, et al. Senile EBV+ B‐cell lymphoproliferative disorders:a clinicopathologic study of 22 patients. Am J Surg Pathol. 2003;27:16‐26. - PubMed
    1. Roberts TK, Chen X, Liao JJ. Diagnostic and therapeutic challenges of EBV‐positive mucocutaneous ulcer: a case report and systematic review of the literature. Exp Hematol Oncol. 2016;5:13. - PMC - PubMed
    1. Ikeda T, Gion Y, Yoshino T, Sato Y. A review of EBV‐positive mucocutaneous ulcers focusing on clinical and pathological aspects. J Clin Exp Hematop. 2019;59:64‐71. - PMC - PubMed

Publication types

LinkOut - more resources