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Case Reports
. 2020 Mar 27;6(7):395-397.
doi: 10.1016/j.hrcr.2020.03.008. eCollection 2020 Jul.

Deletion of entire LMNA gene as a cause of cardiomyopathy

Allison L Cirino  1 , Sarah Cuddy  1 , Neal K Lakdawala  1
Affiliations
Case Reports

Deletion of entire LMNA gene as a cause of cardiomyopathy

Allison L Cirino et al. HeartRhythm Case Rep. .
No abstract available

Keywords: Atrial fibrillation; Chromosomal microarray; Dilated cardiomyopathy; Genetics; Heart block; LMNA.

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Figures

Figure 1
Figure 1
Cardiac imaging results. Late gadolinium enhancement (LGE) cardiac magnetic resonance images, showing the 4-chamber (A), oblique 2-chamber (B), and basal short axis (C) views, demonstrating midmyocardial LGE of the basal septal wall (red arrows), the basal inferior wall (white arrow), and the right ventricular insertion point (green arrow). Marked dilation of the left atrium (LA) can also be seen in A and B.
Figure 2
Figure 2
Microarray results. UCSC Genome Browser (http://genome.ucsc.edu/) image of chromosome 1. The deleted region is marked in red. The OMIM genes included in the deletion are illustrated below, from left to right: LMNA, SEMA4, SLC25A44, PMF1, BGLAP, PAQR6, SMG5, TMEM79, and CCT3. The darker-shaded rectangles denote genes that may be disease causing (LMNA and SEMA4).
See this image and copyright information in PMC

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