Pediatric Sepsis Definition-A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce

Kusum Menon¹, Luregn J Schlapbach^{2

3}, Samuel Akech⁴, Andrew Argent⁵, Kathleen Chiotos⁶, Mohammod Jobayer Chisti⁷, Jemila Hamid⁸, Paul Ishimine⁹, Niranjan Kissoon¹⁰, Rakesh Lodha¹¹, Cláudio Flauzino Oliveira¹², Mark Peters¹³, Pierre Tissieres¹⁴, R Scott Watson¹⁵, Matthew O Wiens^{16

17}, James L Wynn¹⁸, Lauren R Sorce^{19

20}

Affiliations

¹ Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
² Paediatric Critical Care Research Group, Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia.
³ Paediatric ICU, Queensland Children's Hospital, Brisbane, QLD, Australia.
⁴ KEMRI Wellcome Trust Research Program, Oxford, United Kingdom.
⁵ Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and University of Cape Town, Cape Town, South Africa.
⁶ Department of Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
⁷ International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
⁸ Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
⁹ Department of Emergency Medicine, University of California San Diego, San Diego, CA.
¹⁰ Department of Pediatrics, British Columbia Children's Hospital, Vancouver, BC, Canada.
¹¹ Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
¹² Associação de Medicina Intensiva Brasileira, São Paulo, Brazil.
¹³ University College London Great Ormond Street Institute of Child Health, London, United Kingdom.
¹⁴ Hospital de Bicetre, Paris, France.
¹⁵ Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle Children's Hospital, Seattle, WA.
¹⁶ University of British Columbia, Vancouver, BC, Canada.
¹⁷ Mbarara University of Science and Technology, Mbarara, Uganda.
¹⁸ Department of Pediatrics, University of Florida, Gainesville, FL.
¹⁹ Ann & Robert H. Lurie Children's Hospital, Chicago, IL.
²⁰ Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL.

PMID: 32695992
PMCID: PMC7314341
DOI: 10.1097/CCE.0000000000000123

Review

Pediatric Sepsis Definition-A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce

Kusum Menon et al. Crit Care Explor. 2020.

. 2020 Jun 11;2(6):e0123.

doi: 10.1097/CCE.0000000000000123. eCollection 2020 Jun.

Authors

Affiliations

¹ Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
² Paediatric Critical Care Research Group, Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia.
³ Paediatric ICU, Queensland Children's Hospital, Brisbane, QLD, Australia.
⁴ KEMRI Wellcome Trust Research Program, Oxford, United Kingdom.
⁵ Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and University of Cape Town, Cape Town, South Africa.
⁶ Department of Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
⁷ International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
⁸ Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
⁹ Department of Emergency Medicine, University of California San Diego, San Diego, CA.
¹⁰ Department of Pediatrics, British Columbia Children's Hospital, Vancouver, BC, Canada.
¹¹ Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
¹² Associação de Medicina Intensiva Brasileira, São Paulo, Brazil.
¹³ University College London Great Ormond Street Institute of Child Health, London, United Kingdom.
¹⁴ Hospital de Bicetre, Paris, France.
¹⁵ Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle Children's Hospital, Seattle, WA.
¹⁶ University of British Columbia, Vancouver, BC, Canada.
¹⁷ Mbarara University of Science and Technology, Mbarara, Uganda.
¹⁸ Department of Pediatrics, University of Florida, Gainesville, FL.
¹⁹ Ann & Robert H. Lurie Children's Hospital, Chicago, IL.
²⁰ Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL.

PMID: 32695992
PMCID: PMC7314341
DOI: 10.1097/CCE.0000000000000123

Abstract

Objectives: Sepsis is responsible for a substantial proportion of global childhood morbidity and mortality. However, evidence demonstrates major inaccuracies in the use of the term "sepsis" in clinical practice, coding, and research. Current and previous definitions of sepsis have been developed using expert consensus but the specific criteria used to identify children with sepsis have not been rigorously evaluated. Therefore, as part of the Society of Critical Care Medicine's Pediatric Sepsis Definition Taskforce, we will conduct a systematic review to synthesize evidence on individual factors, clinical criteria, or illness severity scores that may be used to identify children with infection who have or are at high risk of developing sepsis-associated organ dysfunction and separately those factors, criteria, and scores that may be used to identify children with sepsis who are at high risk of progressing to multiple organ dysfunction or death.

Data sources: We will identify eligible studies by searching the following databases: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials.

Study selection: We will include all randomized trials and cohort studies published between January 1, 2004, and March 16, 2020.

Data extraction: Data extraction will include information related to study characteristics, population characteristics, clinical criteria, and outcomes.

Data synthesis: We will calculate sensitivity and specificity of each criterion for predicting sepsis and conduct a meta-analysis if the data allow. We will also provide pooled estimates of overall hospital mortality.

Conclusions: The potential risk factors, clinical criteria, and illness severity scores from this review which identify patients with infection who are at high risk of developing sepsis-associated organ dysfunction and/or progressing to multiple organ dysfunction or death will be used to inform the next steps of the Pediatric Sepsis Definition Taskforce.

Keywords: childhood; infection; mortality; organ dysfunction; sepsis; septic shock.

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Conflict of interest statement

The authors have disclosed that they do not have any potential conflicts of interest.

References

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Pediatric Sepsis Definition-A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce

Affiliations

Pediatric Sepsis Definition-A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

Grants and funding

LinkOut - more resources

Full Text Sources