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Multicenter Study
. 2020 Dec;62(12):1444-1449.
doi: 10.1111/dmcn.14628. Epub 2020 Jul 22.

IQ predictors in pediatric opsoclonus myoclonus syndrome: a large international cohort study

Andrew Sheridan  1 , Kush Kapur  2 , Ferne Pinard  2 , Fabienne Dietrich Alber  3 , Susana Camposano  2 , Mike G Pike  4 , Andrea Klein  5   6   7 , Mark P Gorman  2
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Free article
Multicenter Study

IQ predictors in pediatric opsoclonus myoclonus syndrome: a large international cohort study

Andrew Sheridan et al. Dev Med Child Neurol. 2020 Dec.
Free article

Abstract

Aim: To determine predictors of full-scale IQ (FSIQ) in an international pediatric opsoclonus myoclonus syndrome (OMS) cohort.

Method: In this retrospective and prospective cohort study at three academic medical centers (2006-2013), the primary outcome measure, FSIQ, was categorized based on z-score: above average (≥+1), average (+1 to -1), mildly impaired (-1 to -2), and impaired (<-2). Univariate analysis and multivariable linear regression modeling using stepwise selection with Akaike's information criterion was performed to understand the relationship between exposures and FSIQ.

Results: Of 81 participants, 37 with sufficient data had mean FSIQ 84.38 (SD 20.55) and median 90 (40-114) at latest available evaluation (mean age 8y 5mo). Twenty (54%), nine (24.3%), and eight (21.6%) had normal, mildly impaired, and impaired FSIQ respectively. The final multivariable linear regression model included 34 participants with evaluable data: number of relapses occurring before neuropsychological testing (p<0.001) and OMS severity score at last follow-up (p<0.001) predicted FSIQ (adjusted R2 =0.64). There was a mean decrease of 2.4 FSIQ points per OMS relapse.

Interpretation: Number of relapses negatively correlates with FSIQ in pediatric OMS. Demographic and clinical measures available at OMS onset did not predict FSIQ. Strategies to reduce OMS relapses may improve intellectual outcomes.

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References

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