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. 2020 Jul 1;3(7):e2016485.
doi: 10.1001/jamanetworkopen.2020.16485.

Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19)

Pierre Francois Laterre  1 , Bruno François  2 , Christine Collienne  1 , Philippe Hantson  1 , Robin Jeannet  3 , Kenneth E Remy  4   5   6 , Richard S Hotchkiss  5   6   7
Affiliations

Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19)

Pierre Francois Laterre et al. JAMA Netw Open. .

Abstract

This case series examines whether interleukin 7 (IL-7) is associated with restored host protective immunity in patients with severe coronavirus disease 2019 (COVID-19) and immunosuppression.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Hotchkiss reported being an investigator on a sepsis study evaluating interleukin 7 and receiving grants from the National Institutes of Health outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Association of Interleukin 7 (IL-7) With Absolute Lymphocyte Count, Body Temperature, and Pao2:Fio2 Ratio
IL-7 was administered at 3 μg/kg on day 1 and at 10 μg/kg at days 2, 5, 8, and 12. Points indicate means, and whiskers indicate SEs.
See this image and copyright information in PMC

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