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Comment
. 2020 Aug 20;182(4):794-795.
doi: 10.1016/j.cell.2020.06.040. Epub 2020 Jul 3.

Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear

Nathan D Grubaugh  1 , William P Hanage  2 , Angela L Rasmussen  3
Affiliations
Comment

Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear

Nathan D Grubaugh et al. Cell. .

Abstract

In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are largely unknown.

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  • Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
    Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B, Hastie KM, Parker MD, Partridge DG, Evans CM, Freeman TM, de Silva TI; Sheffield COVID-19 Genomics Group; McDanal C, Perez LG, Tang H, Moon-Walker A, Whelan SP, LaBranche CC, Saphire EO, Montefiori DC. Korber B, et al. Cell. 2020 Aug 20;182(4):812-827.e19. doi: 10.1016/j.cell.2020.06.043. Epub 2020 Jul 3. Cell. 2020. PMID: 32697968 Free PMC article.

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