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Review
. 2020 Nov;84(5):e13310.
doi: 10.1111/aji.13310. Epub 2020 Aug 4.

COVID-19 and hydatidiform mole

Ahmed M Abbas  1   2 , Lobna Ahmed  2   3 , Amera S Salem  2   3 , Shimaa H Elsamman  2   3 , Alshaima Refai  2   3 , Safaa K Fathy  2   3 , Omar A Ahmed  4 , Asmaa S Shalotut  5 , Radwa A AbdelWahab  5
Affiliations
Review

COVID-19 and hydatidiform mole

Ahmed M Abbas et al. Am J Reprod Immunol. 2020 Nov.

Abstract

The emergence of coronavirus disease 2019 (COVID-19) as a pandemic threatens the entire world resulting in severe consequences for people's health. Pregnant patients with COVID-19 had immune dysregulation that could result in abnormal pregnancy outcomes such as hydatidiform mole (HM), recurrent pregnancy loss, and early-onset preeclampsia. In this article, we tried to summarize the possible association between COVID-19 and the HM's development by reviewing the role of NOD-Like Receptor (NLR) Family Pyrin Domain Containing 7 (NLRP7), cytokines, zinc, and leukocytes in the pathogenesis of HM.

Keywords: COVID-19; Gestational trophoblastic diseases; Hydatidiform mole; coronavirus.

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Conflict of interest statement

The authors state that there are no conflicts of interest.

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