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Comment
. 2020 Sep;17(9):899-900.
doi: 10.1038/s41423-020-0508-6. Epub 2020 Jul 22.

Functional interaction between sensory neurons and mast cells in the early stage of house dust mite-induced type 2 inflammation and itch: a novel therapeutic target of allergic disease

Miranda Sin-Man Tsang  1   2 , Chun Kwok Wong  3   4   5
Affiliations
Comment

Functional interaction between sensory neurons and mast cells in the early stage of house dust mite-induced type 2 inflammation and itch: a novel therapeutic target of allergic disease

Miranda Sin-Man Tsang et al. Cell Mol Immunol. 2020 Sep.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
A cluster formed between the nociceptor and mast cell in the skin upon house dust mite activation in the early development of type 2 allergic skin inflammation. Allergen house dust mites (D. farinae and D. pteronyssinus) directly activate Tac1-expressing and neuropeptide-producing nociceptive sensory neurons, i.e., peptidergic nociceptors, by degrading epithelial junctions by cysteine proteolytic activity. The gene Tac1 encodes the neuropeptide substance p (SP) precursor. The SP produced is secreted from the ion channel TRPV1+ nociceptor. The secreted SP is then taken up by adjacent mast cells via the cationic molecule receptor MRGPRB2 in mice. This triggers the degranulation of mast cells and drives itchy signals and the development of type 2 skin inflammation that resembles the features of AD in humans
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References

    1. Ostlere LS, Cowen T, Rustin MH. Clin. Exp. Dermatol. 1995;20:462–467. doi: 10.1111/j.1365-2230.1995.tb01378.x. - DOI - PubMed
    1. Toyoda M, et al. Br. J. Dermatol. 2002;147:71–79. doi: 10.1046/j.1365-2133.2002.04803.x. - DOI - PubMed
    1. Wallrapp A, et al. Nature. 2017;549:351–356. doi: 10.1038/nature24029. - DOI - PMC - PubMed
    1. Moriyama S, et al. Science. 2018;359:1056–1061. doi: 10.1126/science.aan4829. - DOI - PubMed
    1. Kashem SW, et al. Immunity. 2015;43:515–526. doi: 10.1016/j.immuni.2015.08.016. - DOI - PMC - PubMed