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Review
. 2020 Jul 20:20:326.
doi: 10.1186/s12935-020-01412-7. eCollection 2020.

LncRNA & Wnt signaling in colorectal cancer

Zeeshan Javed  1 , Khushbukhat Khan  2 , Haleema Sadia  3 , Shahid Raza  4 , Bahare Salehi  5   6 , Javad Sharifi-Rad  7 , William C Cho  8
Affiliations
Review

LncRNA & Wnt signaling in colorectal cancer

Zeeshan Javed et al. Cancer Cell Int. .

Abstract

The outlook for new therapeutic approaches is pivotal to ameliorate the deterioration caused by the abrogated Wnt signaling. Long non-coding RNAs (lncRNAs) are tiny molecules that have begun emerging as vital molecular manager for the regulation of various cellular processes at transcription and translation levels in the colorectal cancer (CRC). Targeting Wnt pathway with lncRNA seems a promising approach to eradicate CRC. However, little is known of their active role in commencing both apoptosis and proliferation in CRC. This article reviews the importance of these molecules in the pathogenesis of CRC and also emphasizes on the development of new therapeutic strategies to cope with the Wnt mediated CRC.

Keywords: Colorectal cancer; Therapeutics strategy; Wnt signaling; lncRNA.

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Conflict of interest statement

Competing interestsNo competing interest.

Figures

Fig. 1
Fig. 1
Interplay between Wnt signaling cascade and lncRNAs: in canonical Wnt signaling several lncRNAs interact with Wnt consequently affect the expression of the targeted genes. Arrows indicate activation and inhibition by the lncRNAs
See this image and copyright information in PMC

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