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Review
. 2019 Dec;7(2):101-120.
doi: 10.1007/s40487-019-0096-8. Epub 2019 Jul 8.

A Review of Immune-Mediated Adverse Events in Melanoma

Lucy Boyce Kennedy  1 , April K S Salama  2
Affiliations
Review

A Review of Immune-Mediated Adverse Events in Melanoma

Lucy Boyce Kennedy et al. Oncol Ther. 2019 Dec.

Abstract

The use of checkpoint inhibitor-based immunotherapy has transformed the treatment landscape for melanoma as well as many other cancer types. With the ability to potentiate tumor-specific immune responses, these agents can result in durable tumor control. However, this activation of the immune system can lead to a unique constellation of side effects, distinct from other cancer therapies, collectively termed immune-mediated adverse events (irAEs). This review will focus on irAEs and guidelines for management related to the most clinically relevant checkpoint inhibitors, those that target programmed death receptor-1 (PD-1) and cytotoxic T lymphocyte antigen-4 (CTLA-4).

Keywords: CTLA-4; Checkpoint inhibitor; Immune-related adverse events (irAEs); Ipilimumab; Melanoma; Nivolumab; PD-1; Pembrolizumab; Toxicity.

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