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Editorial
. 2020 Sep;9(9):481-483.
doi: 10.1002/psp4.12550. Epub 2020 Aug 27.

Initiation of Antiviral Treatment in SARS-CoV2: Modeling Viral Dynamics and Drug Properties

Daniel Scholes Rosenbloom  1 , Ping Zhao  2 , Vikram Sinha  1
Affiliations
Editorial

Initiation of Antiviral Treatment in SARS-CoV2: Modeling Viral Dynamics and Drug Properties

Daniel Scholes Rosenbloom et al. CPT Pharmacometrics Syst Pharmacol. 2020 Sep.
No abstract available

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Conflict of interest statement

D.S.R. and V.S. are employees of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA, and own stock options in Merck & Co., Inc., Kenilworth, NJ, USA. V.S. also reports stock and patents from Eli Lilly and Co. P.Z. is an employee of the Gates Foundation; the foundation has a grant to INSERM to expand their viral dynamic model.

Figures

Figure 1
Figure 1
A conceptual illustration of model presented by Goncalves et al. 3
See this image and copyright information in PMC

Comment on

  • Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load.
    Gonçalves A, Bertrand J, Ke R, Comets E, de Lamballerie X, Malvy D, Pizzorno A, Terrier O, Rosa Calatrava M, Mentré F, Smith P, Perelson AS, Guedj J. Gonçalves A, et al. CPT Pharmacometrics Syst Pharmacol. 2020 Sep;9(9):509-514. doi: 10.1002/psp4.12543. Epub 2020 Aug 7. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32558354 Free PMC article.

References

    1. Schmith, V.D. , Zhou, J. & Lohmer, L.R. Dimitris Rizopoulos ISBN 10: 1439872864. Chapman and Hall/CRC. ISBN 13: 9781439872864.
    1. Fan, J. et al Connecting hydroxychloroquine in vitro antiviral activity to in vivo concentration for prediction of antiviral effect: a critical step in treating COVID‐19 patients. Clin. Infect. Dis. https://doi.org/10.1093/cid/ciaa623. - DOI - PMC - PubMed
    1. Gonçalves, A. et al Timing of antiviral treatment initiation is critical to reduce SARS‐CoV‐2 viral load. CPT Pharma. Syst. Pharmacol. https://doi.org/10.1002/psp4.12543. - DOI - PMC - PubMed
    1. Perelson, A.S. , Rong, L. & Hayden, F.G. Combination antiviral therapy for influenza: 329 predictions from modeling of human infections. J. Infect. Dis. 205, 1642–1645 (2012). - PMC - PubMed
    1. Baccam, P. , Beauchemin, C. , Macken, C.A. , Hayden, F.G. & Perelson, A.S. Kinetics of influenza A virus infection in humans. J. Virol. 80, 7590–7599 (2006). - PMC - PubMed