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Review
. 2020 Dec;127(13):1590-1597.
doi: 10.1111/1471-0528.16425. Epub 2020 Aug 26.

Placental growth factor in suspected preterm pre-eclampsia: a review of the evidence and practicalities of implementation

A Hurrell  1 , A Beardmore-Gray  1 , K Duhig  1 , L Webster  1 , L C Chappell  1 , A H Shennan  1
Affiliations
Review

Placental growth factor in suspected preterm pre-eclampsia: a review of the evidence and practicalities of implementation

A Hurrell et al. BJOG. 2020 Dec.

Abstract

Despite extensive research, the pathophysiology and prevention of pre-eclampsia remain elusive, diagnosis is challenging, and pre-eclampsia remains associated with adverse maternal and perinatal outcomes. Angiogenic biomarkers, including placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1), have been identified as valuable biomarkers for preterm pre-eclampsia, accelerating diagnosis and reducing maternal adverse outcomes by risk stratification, with enhanced surveillance for high-risk women. PlGF-based testing is increasingly being implemented in clinical practice in several countries. This review provides healthcare providers with an understanding of the evidence for PlGF-based testing and describes the practicalities and challenges to implementation. TWEETABLE ABSTRACT: Placental growth factor in pre-eclampsia: evidence and implementation of testing.

Keywords: Angiogenic biomarkers; placental growth factor; pre-eclampsia; soluble fms-like tyrosine kinase 1.

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References

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